Acetyl fluoride
Acetyl fluoride (CAS: 557-99-3, CH3COF) is an organofluorine compound with a molecular weight of 62.04 g/mol. It is a colourless liquid with a low boiling point, often employed as a reagent in organic synthesis. Its reactivity makes it valuable for introducing acetyl groups and in the preparation of various organic intermediates. Available from Tech Serve Solutions with an assay of 99%.

Organic Synthesis Reagent
Acetyl fluoride serves as a versatile reagent in organic chemistry, particularly for acylation reactions. It is used to introduce the acetyl group (CH3CO-) into various organic molecules, facilitating the synthesis of complex compounds.
Precursor for Specialty Chemicals
This compound acts as a precursor in the synthesis of a range of specialised organic chemicals. Its reactivity allows for controlled transformations, leading to valuable intermediates for further chemical processing.
Fluorinating Agent
In certain synthetic pathways, acetyl fluoride can be utilised for fluorination processes. It enables the incorporation of fluorine atoms into organic structures, a common requirement in pharmaceutical and material science research.
| Molecular weight | 62.04 |
|---|---|
| Linear formula | CH3COF |
| Assay | 99% |
| Boiling point | 20-21 °C(lit.) |
| Vapour pressure | 15.61 psi (20 °C) |
| Melting point | −84 °C(lit.) |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US) |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Acetyl fluoride used for?
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Acetyl fluoride is primarily used as a reagent in organic synthesis for acylation reactions and as a precursor for speciality chemicals and fluorination processes.
What is the CAS number and formula for Acetyl fluoride?
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The CAS number for Acetyl fluoride is 557-99-3, and its chemical formula is CH3COF.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Acetyl fluoride with a minimum assay of 99%. This product is not represented as USP, BP, EP, or other pharmacopoeial grades.
How should Acetyl fluoride be handled safely?
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Acetyl fluoride is a corrosive substance that causes severe skin burns and eye damage (H314). Handling requires appropriate personal protective equipment, including faceshields, gloves, goggles, and respiratory protection. It should be handled in a well-ventilated area, and immediate medical attention sought in case of contact or exposure.
How is Acetyl fluoride packed, shipped, and exported?
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Acetyl fluoride is packed and shipped according to relevant dangerous goods regulations (UN 3265, Class 8, Packing Group I). Tech Serve Solutions offers expert export services for this chemical to qualified clients worldwide.
How can I request a quote or sample of Acetyl fluoride?
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To request a quote or sample of Acetyl fluoride, please contact our sales team through the website or via the provided contact details, specifying your requirements.
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