7-Methoxyindole
7-Methoxyindole (CAS: 3189-22-8, C9H9NO) is a heterocyclic organic compound with a molecular weight of 147.17 g/mol. It serves as a key building block in chemical synthesis, particularly for the development of novel pharmaceutical agents. Its applications span the creation of potential anticancer immunomodulators, inhibitors of crucial cellular signalling pathways like ILK, and compounds targeting viral replication.
- IUPAC
- NSC 100739
Anticancer Agent Precursor
7-Methoxyindole is used as a reactant in the preparation of pyridyl-ethenyl-indole derivatives. These compounds are investigated as potential anticancer immunomodulators, specifically by targeting tryptophan dioxygenase.
Kinase Inhibitor Synthesis
This compound is a valuable intermediate for synthesising indolylindazoles and indolylpyrazolopyridines. These molecules are explored for their potential as inhibitors of interleukin-2 inducible T cell kinase (ITK).
Antiviral Compound Development
7-Methoxyindole is employed in the synthesis of benzoylpiperazinyl-indolyl ethane dione derivatives. These are studied for their potential as inhibitors of HIV-1 replication.
Histone Deacetylase Inhibitor Intermediate
It acts as a reactant in the production of bis(indolyl)alkanehydroxamic acids, which are researched for their role as histone deacetylase (HDAC) inhibitors.
MAPK Pathway Modulator Synthesis
7-Methoxyindole is utilised in the synthesis of β-carboline-1-carboxylic acids. These compounds are investigated for their inhibitory effects on mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2).
| Molecular weight | 147.17 |
|---|---|
| Empirical formula | C9H9NO |
| Assay | 97% |
| Boiling point | 108-110 °C/0.3 mmHg(lit.) |
| Density | 1.126 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.612(lit.) |
| Application | • Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators• Reactant for preparation of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors• Reactant for preparation of benzoylpiperazinyl-indolyl ethane dione derivatives as HIV-1 inhibitors• Reactant for preparation of bis(indolyl)alkanehydroxamic acids as histone deacetylase inhibitors• Reactant for preparation of β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | >113 °C / >235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-37/38-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 7-Methoxyindole used for?
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7-Methoxyindole is used as a reactant and building block in the synthesis of various potential pharmaceutical agents, including anticancer immunomodulators, kinase inhibitors, antiviral compounds, and histone deacetylase inhibitors.
What is the CAS number and formula for 7-Methoxyindole?
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The CAS number for 7-Methoxyindole is 3189-22-8, and its molecular formula is C9H9NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 7-Methoxyindole with an assay of 97%. This product is supplied for research and laboratory use and is not represented as meeting USP, BP, EP, or any pharmacopoeia standards.
How should 7-Methoxyindole be handled safely?
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7-Methoxyindole is labelled with Danger. It is harmful if swallowed (H302), causes skin irritation (H315), causes serious eye damage (H318), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves, should be used. Ensure good ventilation.
Is 7-Methoxyindole a controlled substance?
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The provided data does not indicate that 7-Methoxyindole (CAS: 3189-22-8) is a scheduled or controlled substance.
How can I get a quote or sample of 7-Methoxyindole?
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To request a quote or a sample of 7-Methoxyindole, please contact the Tech Serve Solutions sales team through our website or via direct inquiry, providing your specific requirements.
How is 7-Methoxyindole shipped?
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7-Methoxyindole is exported globally by Tech Serve Solutions. Specific shipping and packaging details will be confirmed upon order placement and are subject to relevant regulations.
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