6-Methoxypyridine-2-boronic acid N-phenyldiethanolamine ester
6-Methoxypyridine-2-boronic acid N-phenyldiethanolamine ester (CAS: 872054-59-6) is an organometallic reagent with the molecular formula C16H19BN2O3 and a molecular weight of 298.14. This boronate ester serves as a valuable building block in organic synthesis. It is particularly employed as a reactant in the preparation of various complex organic molecules, including sulfonamides and oxyindole derivatives, which are investigated for their pharmacological properties.
- IUPAC
- 6-Methoxy-2-pyridineboronic acid-N-phenyldiethanolamine ester
- Synonyms
- 6-Methoxy-2-pyridineboronic acid-N-phenyldiethanolamine ester
Preparation of Alkylated Sulfonamides
This compound is utilized as a reactant for the preparation of alkylated sulfonamides through alkylation reactions with alcohols, often catalysed by hybrid silver and molybdenum systems.
Synthesis of Oxyindole Derivatives
It serves as a key intermediate in the synthesis of 7-disubstituted oxyindoles, which are explored for their potential as EP3 receptor antagonists.
N-Alkylation of Sulfonamides
The boronate ester is employed in the preparation of N-substituted sulfonamides via ferrous chloride-catalyzed N-alkylation reactions with benzylic alcohols.
Synthesis of Acyl Transfer Intermediates
It is used in the preparation of (alkyl)hydroxybenzimidazoles through O- to N-acyl transfer reactions, serving as intermediates for EP3 receptor antagonists.
Preparation of N-Arylsulfonyl Acrylamides
This compound facilitates the synthesis of N-arylsulfonyl β-[(aryloxy)indolyl]acrylamides, which are investigated as potent and selective EP3 receptor antagonists.
| Molecular weight | 298.14 |
|---|---|
| Empirical formula | C16H19BN2O3 |
| Application | Reactant for:• Preparation of alkylated sulfonamides via alkylation with alcohols catalyzed by Ag/Mo hybrid1• Preparation of 7-disubstituted oxyindoles as EP3 receptor antagonists2• Preparation of N-substituted sulfonamides via ferrous chloride-catalyzed N-alkylation with benzylic alcohols3• Preparation of (alkyl)hydroxybenzimidazoles, via a O- to N-acyl transfer reaction, as intermediates for EP3 receptor antagonists4• Preparation of N-arylsulfonyl β-[(aryloxy)indolyl]acrylamides as potent and selective EP3 receptor antagonists5 |
| Melting point | 210 °C (dec.)(lit.) |
Hazard statements
- H228Flammable solid
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3175 4.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 37/38-41-67 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Methoxypyridine-2-boronic acid N-phenyldiethanolamine ester used for?
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This compound is used as a reactant in various organic synthesis applications, including the preparation of alkylated sulfonamides, oxyindole derivatives, and other complex organic molecules investigated for pharmacological properties.
What is the CAS number and chemical formula?
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The CAS number is 872054-59-6 and the empirical formula (Hill notation) is C16H19BN2O3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound for research and development purposes. Please refer to the product's Certificate of Analysis for specific assay and purity details. TSS does not represent this product as meeting USP, BP, EP, or other pharmacopoeia standards.
What are the safety considerations for handling this chemical?
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This compound is classified with GHS02, GHS05, and GHS07 symbols, carrying a Danger signal word. It is a flammable solid (H228), causes skin irritation (H315), causes serious eye damage (H318), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
Can Tech Serve Solutions export this chemical internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents and can facilitate international shipments.
How can I request a quote or sample?
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To request a quote or a sample, please use the 'Request a Quote' or 'Request a Sample' button on the product page, or contact our sales team directly.
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