6-Methoxyindole-2-carboxylic acid
6-Methoxyindole-2-carboxylic acid (CAS: 16732-73-3), with the molecular formula C10H9NO3 and a molecular weight of 191.18 g/mol, is a key indole derivative. This compound serves as a valuable building block in organic synthesis. It is frequently employed as a reactant in the preparation of complex heterocyclic compounds, including pyrazinoindolediones and isoquinolinecarboxamides, and finds utility in the synthesis of various indole derivatives.
- IUPAC
- NSC 27988
Demethylation Reactions
Utilised as a reactant in demethylation reactions, often facilitated by ionic liquids under microwave irradiation.
Ugi Reaction and Cyclization
Serves as a reactant in the preparation of pyrazinoindoledione through Ugi reactions followed by microwave-assisted cyclisation.
Opioid Receptor Antagonist Precursors
Acts as a reactant in the synthesis of isoquinolinecarboxamides and related derivatives investigated for their potential as opioid receptor antagonists.
Indole Fatty Alcohol Synthesis
Functions as a synthetic intermediate for the preparation of indole fatty alcohol derivatives.
Melatonin Antagonist Synthesis
Employed as a reactant in the preparation of acylaminoalkylindoles designed as MT2-selective melatonin antagonists.
| Molecular weight | 191.18 |
|---|---|
| Empirical formula | C10H9NO3 |
| Assay | 95% |
| Application | • Reactant for demethylation reactions using ionic liquids under microwave irradiation1• Reactant for preparation of pyrazinoindoledione via Ugi reaction and microwave-assisted cyclization2• Reactant for preparation of isoquinolinecarboxamides and their derivatives as opioid receptor antagonists3• Synthetic intermediate for preparation of indole fatty alcohol derivatives4• Reactant for preparation of acylaminoalkylindoles as MT2-selective melatonin antagonists5 |
| Melting point | 198-203 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Methoxyindole-2-carboxylic acid used for?
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6-Methoxyindole-2-carboxylic acid is used as a reactant in various organic synthesis pathways, including demethylation reactions, preparation of pyrazinoindolediones, synthesis of opioid receptor antagonist precursors, and preparation of indole fatty alcohol and melatonin antagonist derivatives.
What are the CAS number and formula for 6-Methoxyindole-2-carboxylic acid?
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The CAS number is 16732-73-3 and the empirical formula is C10H9NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 6-Methoxyindole-2-carboxylic acid with an assay of 95%. This product is suitable for research and chemical synthesis. TSS does not represent this product as USP, BP, or EP grade.
How should 6-Methoxyindole-2-carboxylic acid be handled?
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Warning: Causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Avoid breathing dust. Ensure good ventilation. Wear protective gloves, eye protection, and face protection. In case of contact with eyes, rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.
How is 6-Methoxyindole-2-carboxylic acid packed and shipped?
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6-Methoxyindole-2-carboxylic acid is carefully packed for secure transit and is available for export globally by Tech Serve Solutions.
How can I request a sample or quote for 6-Methoxyindole-2-carboxylic acid?
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Please contact Tech Serve Solutions directly through our website or by phone to request a sample or a quotation for 6-Methoxyindole-2-carboxylic acid.
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