6-Methoxy-2-pyridylzinc bromide solution
6-Methoxy-2-pyridylzinc bromide solution (CAS 352530-39-3) is an organozinc reagent with the empirical formula C6H6BrNOZn and a molecular weight of 253.41 g/mol. Supplied as a 0.5 M solution in Tetrahydrofuran (THF), it is a valuable building block in organic synthesis. Its primary applications lie in cross-coupling reactions, particularly for the introduction of the 6-methoxy-2-pyridyl moiety into complex organic molecules, facilitating advancements in pharmaceutical and materials science research.
Organometallic Cross-Coupling Reactions
This organozinc bromide serves as a key nucleophile in various palladium-catalyzed cross-coupling reactions, such as Negishi couplings. It enables the efficient formation of carbon-carbon bonds, facilitating the synthesis of complex heteroaromatic compounds.
Synthesis of Pharmaceutical Intermediates
The 6-methoxy-2-pyridyl group is a common structural motif in biologically active molecules. This reagent is instrumental in constructing advanced intermediates for drug discovery and development, streamlining synthetic pathways.
Materials Science Applications
Organozinc reagents are employed in the synthesis of novel organic materials. 6-Methoxy-2-pyridylzinc bromide can be utilised in the development of functional organic materials with specific electronic or optical properties.
| Molecular weight | 253.41 |
|---|---|
| Empirical formula | C6H6BrNOZn |
| Boiling point | 65 °C |
| Density | 0.99 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 19-36/37-40 |
| Safety statements (S) | 26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Methoxy-2-pyridylzinc bromide solution used for?
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6-Methoxy-2-pyridylzinc bromide solution (CAS 352530-39-3) is primarily used as a reagent in organometallic cross-coupling reactions, particularly for introducing the 6-methoxy-2-pyridyl group into organic molecules for pharmaceutical intermediate and materials science applications.
What are the CAS number and formula for 6-Methoxy-2-pyridylzinc bromide solution?
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The CAS number is 352530-39-3, and the empirical formula is C6H6BrNOZn.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 6-Methoxy-2-pyridylzinc bromide solution at a concentration of 0.5 M in THF. TSS does not represent this product as USP, BP, EP or pharmacopoeia grade.
What are the safety and handling considerations for this product?
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This reagent is flammable and can form explosive peroxides. It is an irritant to the eyes, respiratory system, and skin (H319, H335). It is also suspected of causing cancer (H351). Handle under an inert atmosphere in a well-ventilated area, away from heat and ignition sources, wearing appropriate personal protective equipment.
How is 6-Methoxy-2-pyridylzinc bromide solution shipped and exported?
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This product is shipped as a regulated material (UN 2924, Packing Group II). Tech Serve Solutions is a global supplier and exporter experienced in handling and shipping hazardous chemicals worldwide, complying with all relevant transport regulations.
How can I request a sample or quote for 6-Methoxy-2-pyridylzinc bromide solution?
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To request a sample or a quotation, please contact our sales team via the website or direct email, providing your contact details and the quantity required.
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