6-Methoxy-2-naphthylmagnesium bromide solution
6-Methoxy-2-naphthylmagnesium bromide solution (CAS: 38046-82-1) is an organometallic compound with the empirical formula C11H9BrMgO and a molecular weight of 261.40 g/mol. Supplied as a 0.5 M solution in THF, this Grignard reagent is a key intermediate in organic synthesis, facilitating the formation of carbon-carbon bonds. It is primarily utilised in the preparation of complex organic molecules, pharmaceutical intermediates, and fine chemicals where precise functionalization of aromatic systems is required.
Aryl Synthesis
As a Grignard reagent, 6-Methoxy-2-naphthylmagnesium bromide is instrumental in introducing the 6-methoxy-2-naphthyl moiety into organic molecules through nucleophilic addition and substitution reactions. This is crucial for building complex aromatic structures.
Pharmaceutical Intermediate Production
This compound serves as a valuable building block in the multi-step synthesis of active pharmaceutical ingredients (APIs). Its reactivity allows for the regioselective construction of pharmacologically relevant scaffolds.
Fine Chemical Manufacturing
It is employed in the synthesis of various fine chemicals and specialty materials. The reagent enables the precise introduction of the methoxynaphthyl group, contributing to the specific properties of the target compounds.
Organic Synthesis Reagent
Its role as an organometallic reagent makes it indispensable for chemists undertaking sophisticated organic transformations. It facilitates the creation of new C-C bonds under relatively mild conditions when handled appropriately.
| Molecular weight | 261.40 |
|---|---|
| Empirical formula | C11H9BrMgO |
| Density | 0.966 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -25 °C / -13 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Methoxy-2-naphthylmagnesium bromide solution used for?
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This solution is primarily used as a Grignard reagent in organic synthesis for introducing the 6-methoxy-2-naphthyl group into target molecules, serving as a key intermediate in the production of pharmaceuticals and fine chemicals.
What are the CAS number and formula for this compound?
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The CAS number is 38046-82-1, and the empirical formula is C11H9BrMgO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 0.5 M solution in Tetrahydrofuran (THF). We do not specify pharmacopoeia grades (USP, EP, BP) unless explicitly stated, and this product is not represented as such.
How should 6-Methoxy-2-naphthylmagnesium bromide solution be handled and stored?
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This is a Danger-labelled substance (H225, H319, H335, H351) that is highly flammable (flash point -25 °C) and may form explosive peroxides. It requires careful handling in a well-ventilated area, away from ignition sources, and storage at 2-8°C to maintain stability and safety.
Is this product shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and this product can be shipped internationally, subject to regulatory compliance.
How can I request a quote or sample?
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Please contact our sales team via the website or direct email to request a quote or sample of 6-Methoxy-2-naphthylmagnesium bromide solution.
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