6-Aminoindole
6-Aminoindole (CAS: 5318-27-4), with the molecular formula C8H8N2 and a molecular weight of 132.16 g/mol, is a valuable chemical intermediate. This indole derivative serves as a crucial building block in organic synthesis, particularly for the development of novel pharmaceutical agents. Its applications span the creation of inhibitors for various cellular targets, including mTOR protein, efflux pumps, and transcription factors, as well as agents targeting protein kinases and ion channels.
- IUPAC
- Indol-6-ylamine,NSC 82379
Pharmaceutical Synthesis
6-Aminoindole is a key reactant in the synthesis of diverse biologically active compounds. It has been used to prepare inhibitors of mammalian target of rapamycin (mTOR) protein and potent DNA-topoisomerase II poisons with anti-MDR activity.
Drug Discovery Intermediate
This compound facilitates the development of novel therapeutics. It is employed in the synthesis of inhibitors of the AcrAB-TolC efflux pump and inhibitors of Gli1-mediated transcription within the Hedgehog pathway.
Development of Analgesics
6-Aminoindole serves as a precursor for potential pain management drugs. It is utilised in creating blockers of the Nav1.8 sodium channel, investigated for treating neuropathic and inflammatory pain, and TRPV1 antagonists.
Kinase Inhibitor Research
The compound is a building block for research into protein kinase inhibitors. It is used in the preparation of Protein Kinase C θ (PKCθ) inhibitors.
| Molecular weight | 132.16 |
|---|---|
| Empirical formula | C8H8N2 |
| Assay | 97% |
| Storage temperature | −20°C |
| Application | Reactant for preparation of:• Inhibitors of mammalian target of rapamycin (mTOR) protein1• Inhibitors of the AcrAB-TolC efflux pump2• Inhibitors of Gli1-mediated transcription in the Hedgehog pathway3• Potent DNA-topoisomerase II poisons and anti-MDR agents4• Protein kinase C θ (PKCθ) inhibitors5• Piperidine carboxamide as transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonists6• Potent and selective blockers of the Nav1.8 sodium channel as potential analgesics for the treatment of neuropathic and inflammatory pain7• 5,6-fused heteroaromatic ureas as TRPV1 antagonists8• Allosteric enhancers of the A3 adenosine receptor9• Human liver glycogen phosphorylase (HLGP) inhibitors for the treatment of type 2 d |
| Melting point | 75-79 °C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Aminoindole used for?
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6-Aminoindole is primarily used as a reactant in organic synthesis and pharmaceutical research. It is a building block for preparing various inhibitors of cellular targets like mTOR protein, efflux pumps, transcription factors, protein kinases, and ion channels, as well as potential analgesics and anti-cancer agents.
What are the CAS number and formula for 6-Aminoindole?
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The CAS number for 6-Aminoindole is 5318-27-4, and its empirical formula is C8H8N2.
What grade and purity does Tech Serve Solutions supply for 6-Aminoindole?
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Tech Serve Solutions supplies 6-Aminoindole with a minimum purity of 97%. This product is intended for chemical synthesis and research purposes, and is not represented as USP, BP, EP, or other pharmacopoeia grades.
What are the safety and handling precautions for 6-Aminoindole?
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6-Aminoindole is classified with a GHS07 symbol and a Warning signal word. It carries hazard statements H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Handle in a well-ventilated area and avoid breathing dust.
Is 6-Aminoindole a controlled substance?
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The provided data does not indicate that 6-Aminoindole (CAS: 5318-27-4) is a controlled substance.
How is 6-Aminoindole packed and shipped by Tech Serve Solutions?
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Tech Serve Solutions packages and exports fine chemicals like 6-Aminoindole according to international shipping regulations. Specific packaging details are available upon request for quotations.
How can I request a sample or quote for 6-Aminoindole?
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To request a sample or a quotation for 6-Aminoindole, please contact the Tech Serve Solutions sales department through our official website or direct inquiry channels.
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