5-Nitroindole
5-Nitroindole (CAS: 6146-52-7, Formula: C8H6N2O2, MW: 162.15) is a chemical intermediate primarily used as a building block in organic synthesis. Its indole core, substituted with a nitro group, makes it a valuable precursor for the development of diverse biologically active compounds. It serves as a key reactant in the synthesis of pharmaceuticals, including potential anticancer, antifungal, and antiviral agents, as well as modulators for neurological targets.
- IUPAC
- NSC 520594
Pharmaceutical Synthesis
Utilised as a reactant in the preparation of various pharmaceutically active compounds. This includes analogues of 2-oxo-1-pyrrolidine, potential anticancer immunomodulators, protein kinase inhibitors, and agents targeting the human immunodeficiency virus (HIV-1).
Anticancer and Antivascular Agents
Serves as a precursor for compounds with potential anticancer activity and antivascular properties. Research indicates its use in developing selective anti-leukemic agents and potential anticancer agents.
Neurological Receptor Modulators
A reactant in the synthesis of positive allosteric modulators of Metabotropic Glutamate Receptor 4 (mGlu4). This is relevant for developing agents that interact with neurological pathways.
Antifungal and Antiviral Research
Employed in the synthesis of potential antifungal agents and anti human immunodeficiency virus subtype 1 (HIV-1) agents, highlighting its utility in developing treatments for infectious diseases.
Cannabinoid Receptor Antagonists
Used in the synthetic pathway for cannabinoid receptor type 1 (CB1) antagonists, indicating its role in research related to cannabinoid receptor modulation.
| Molecular weight | 162.15 |
|---|---|
| Empirical formula | C8H6N2O2 |
| Assay | 98% |
| Application | Reactant for preparation of:• Pharmaceutically active 2-oxo-1-pyrrolidine analogues1• Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators2• Protein Kinase Inhibitors and antiproliferative agents3• Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu4)4• Antifungal agents5• Cannabinoid receptor type 1 (CB1) antagonists6• Potential anticancer agents7• Potential antivascular agents8• Selective Anti-leukemic agents9• Anti human immunodeficiency virus subtype 1 (HIV-1) agents10 |
| Melting point | 140-142 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Nitroindole used for?
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5-Nitroindole is used as a reactant in organic synthesis, particularly for preparing pharmaceutically active compounds such as potential anticancer, antifungal, antiviral agents, and modulators of neurological targets like mGlu4 and CB1 receptors.
What are the CAS number and formula for 5-Nitroindole?
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The CAS number for 5-Nitroindole is 6146-52-7, and its empirical formula is C8H6N2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Nitroindole with an assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling considerations for 5-Nitroindole?
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5-Nitroindole is labelled with Danger. It is harmful if swallowed (H302) and causes serious eye damage (H318). Appropriate personal protective equipment, including a dust mask (N95 type), eyeshields, faceshields, and gloves, should be worn. Ensure good ventilation. In case of eye contact, rinse cautiously with water for several minutes, removing contact lenses if present and easy to do. Continue rinsing.
Is 5-Nitroindole packed, shipped, or exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 5-Nitroindole.
How can I request a sample or quote for 5-Nitroindole?
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Please contact our sales team through our website or direct inquiry channels to request a sample or obtain a quotation for 5-Nitroindole.
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