5-Nitroisatin
5-Nitroisatin (CAS: 611-09-6; Formula: C8H4N2O4; MW: 192.13) is a key chemical intermediate, primarily recognised as a reactant in organic synthesis. It is crucial for the preparation of a diverse range of biologically active compounds, including potential antibacterial, antifungal, antimycobacterial, and anthelmintic agents. Its utility extends to the synthesis of novel spiro[indole-thiazolidinones] and anticonvulsant agents, underscoring its importance in medicinal chemistry research.
- IUPAC
- 5-Nitroindole-2,3-dione,5-Nitrosotin,NSC 525798
Synthesis of Antimicrobial Agents
5-Nitroisatin serves as a foundational building block for synthesising compounds with potential antibacterial, antifungal, and antimycobacterial activities. Its structure allows for modification to create novel agents targeting various microbial pathogens.
Preparation of Spirocyclic Scaffolds
This compound is employed in the construction of medicinally significant spiro[indole-thiazolidinone] structures. These scaffolds are explored for a range of pharmaceutical applications, including potential anticonvulsant properties.
Development of Antiviral and Anthelmintic Compounds
Research utilises 5-Nitroisatin in the synthesis pathways for potential anti-human immunodeficiency virus (HIV) agents and various anthelmintic compounds. This highlights its versatility in drug discovery.
Enzyme Inhibitor Synthesis
5-Nitroisatin is a precursor for creating inhibitors of enzymes such as human transglutaminase 2 and acetylcholinesterase. These inhibitors are of interest for therapeutic interventions in various diseases.
| Molecular weight | 192.13 |
|---|---|
| Empirical formula | C8H4N2O4 |
| Assay | 97% |
| Application | Reactant for preparation of:• Potential antibacterial and antifungal agents1• spiro[indole-thiazolidinones] as a medicinally important scaffold2• Potential antimycobacterial agents3• Anticonvulsant agents4• Inhibitors of human transglutaminase 25• Anthelmintic agents6• Anti-human immunodeficiency virus (HIV) agents7• Antimicrobial agents8• Potential antitubercular agents9• Inhibitors of acetylcholinesterase10 |
| Melting point | 251 °C (dec.)(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H332Harmful if inhaled
- H351Suspected of causing cancer
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-40 |
| Safety statements (S) | 7-22-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Nitroisatin used for?
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5-Nitroisatin (CAS: 611-09-6) is primarily used as a reactant in organic synthesis for the preparation of a wide array of biologically active compounds, including potential antibacterial, antifungal, antimycobacterial, anticonvulsant, anthelmintic, antiviral, and enzyme inhibitory agents. It is also a key intermediate for producing spiro[indole-thiazolidinones].
What is the CAS number and formula for 5-Nitroisatin?
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The CAS number for 5-Nitroisatin is 611-09-6, and its empirical formula is C8H4N2O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Nitroisatin with an assay of 97%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated in the product specifications.
How should 5-Nitroisatin be handled safely?
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5-Nitroisatin is classified with GHS07 and GHS08 symbols and a Warning signal word. It carries hazard statements H302 (Harmful if swallowed), H312 (Harmful in contact with skin), H332 (Harmful if inhaled), and H351 (Suspected of causing cancer). Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection (type N100 or P3), is essential. Handle with care, avoiding exposure and in well-ventilated areas, and follow P280 precautionary statements.
Is 5-Nitroisatin a controlled substance?
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The provided data does not indicate that 5-Nitroisatin is a controlled substance.
How is 5-Nitroisatin packed, shipped, and exported?
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Tech Serve Solutions exports fine chemicals globally. Specific packing and shipping details are provided upon order confirmation, adhering to all relevant international regulations for chemical transport.
How can I request a sample or quote for 5-Nitroisatin?
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To request a sample or quote for 5-Nitroisatin, please use the contact form on our website or reach out to our sales team directly with your inquiry, referencing the product name and CAS number (611-09-6).
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