5-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid
5-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid (CAS: 499-78-5), a pyran derivative with the molecular formula C6H4O5 and a molecular weight of 156.09 g/mol, serves as a key building block in organic synthesis. It is primarily utilised in constructing the colchicine ring skeleton through intramolecular olefin-α-pyrone cycloaddition reactions. TSS supplies this compound at a minimum assay of 97%.
- IUPAC
- 2-Carboxy-5-hydroxy-4-pyrone,Comenic acid
- Synonyms
- Comenic acid2-Carboxy-5-hydroxy-4-pyrone
Colchicine Synthesis
This compound is a crucial precursor for the synthesis of the colchicine ring skeleton. It enables intramolecular olefin-α-pyrone cycloaddition reactions, a key step in building complex polycyclic structures.
Heterocyclic Building Block
As a functionalised pyran derivative, it is valuable for constructing various heterocyclic compounds. Its structure offers reactive sites for further chemical modifications and elaborations.
Organic Synthesis Intermediate
It acts as a versatile intermediate in general organic synthesis, particularly in reactions requiring a diene or dienophile component with specific oxygenation patterns.
| Molecular weight | 156.09 |
|---|---|
| Empirical formula | C6H4O5 |
| Assay | 97% |
| Application | Building block for an intramolecular olefin-α-pyrone cycloaddition providing the colchicine ring skeleton.1 |
| Melting point | 284-294 °C |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid used for?
+
5-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid (CAS: 499-78-5) is used as a building block for an intramolecular olefin-α-pyrone cycloaddition, which provides the colchicine ring skeleton. It is also a useful intermediate in general organic synthesis and for constructing other heterocyclic compounds.
What are the CAS number and molecular formula for 5-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid?
+
The CAS number is 499-78-5 and the molecular formula is C6H4O5.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 5-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid with a minimum assay of 97%. This product is not represented as USP, BP, or EP grade.
How should 5-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid be handled?
+
According to GHS, this compound is classified with a Warning signal word and carries the hazard statement H302 (Harmful if swallowed). Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves.
Is this product available for international export?
+
Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 5-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid.
How can I request a sample or quote for this chemical?
+
To request a sample or obtain a quote for 5-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid, please use the contact form on our website or reach out to our sales team directly.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis