5-Fluoro-2-(trifluoromethyl)benzoyl chloride
5-Fluoro-2-(trifluoromethyl)benzoyl chloride (CAS: 216144-70-6) is a fluorinated organic building block with the linear formula FC<sub>6</sub>H<sub>3</sub>(CF<sub>3</sub>)COCl and a molecular weight of 226.56 g/mol. This reactive acid halide is primarily utilised as an intermediate in the synthesis of complex organic molecules, particularly within the pharmaceutical and agrochemical industries. Its structure incorporates both a fluorine atom and a trifluoromethyl group, making it a valuable reagent for introducing these functionalities into target compounds.
Organic Synthesis Intermediate
This compound serves as a key intermediate in multi-step organic syntheses. It readily reacts with nucleophiles, enabling the formation of esters, amides, and other derivatives crucial for drug discovery and development.
Fluorinated Compound Synthesis
Its structure makes it an ideal starting material for the production of advanced fluorinated organic compounds. The presence of the trifluoromethyl and fluoroaryl groups is desirable in many pharmaceutical and agrochemical applications for modulating properties like lipophilicity and metabolic stability.
Reagent in Chemical Research
5-Fluoro-2-(trifluoromethyl)benzoyl chloride is employed in academic and industrial research laboratories for the development of novel chemical entities and synthetic methodologies.
| Molecular weight | 226.56 |
|---|---|
| Linear formula | FC6H3(CF3)COCl |
| Assay | 97% |
| Boiling point | 169 °C(lit.) |
| Density | 1.5 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.463(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 87 °C / 188.6 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 23-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Fluoro-2-(trifluoromethyl)benzoyl chloride used for?
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5-Fluoro-2-(trifluoromethyl)benzoyl chloride is used as a versatile intermediate in organic synthesis, particularly for creating fluorinated organic compounds for pharmaceutical and agrochemical applications.
What are the CAS number and formula for this chemical?
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The CAS number is 216144-70-6, and its linear formula is FC<sub>6</sub>H<sub>3</sub>(CF<sub>3</sub>)COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with a minimum assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should 5-Fluoro-2-(trifluoromethyl)benzoyl chloride be handled?
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This compound is corrosive and causes severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment, including gloves, goggles, face shield, and a suitable respirator. Ensure adequate ventilation and avoid contact with moisture.
Is this product packed and shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and this product is shipped internationally in compliance with all relevant regulations (UN 3265, Class 8, PG II).
How can I request a sample or quote?
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Please visit the product page on our website and use the 'Request a Quote' or 'Request a Sample' function, or contact our sales team directly.
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