5-Fluoro-2-methoxyaniline
5-Fluoro-2-methoxyaniline (CAS: 1978-39-8), with the molecular formula C7H8FNO and a molecular weight of 141.14 g/mol, is a fluorinated aromatic amine. This compound serves as a valuable building block in organic synthesis, particularly within the pharmaceutical and agrochemical industries. Its structure, featuring both fluorine and methoxy substituents on an aniline core, allows for diverse chemical transformations.
- IUPAC
- 2-Amino-4-fluoroanisole,5-Fluoro-2-methoxybenzenamine,5-Fluoro-o-anisidine
- Synonyms
- 2-Amino-4-fluoroanisole5-Fluoro-2-methoxybenzenamine5-Fluoro-o-anisidine

Pharmaceutical Intermediate
5-Fluoro-2-methoxyaniline is employed as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs). Its fluorinated aromatic structure can impart desirable pharmacokinetic properties to drug molecules.
Agrochemical Synthesis
This compound finds utility in the development of novel agrochemicals, including herbicides, fungicides, and insecticides. The introduction of fluorine can enhance the efficacy and metabolic stability of these agricultural products.
Materials Science
The unique electronic and structural properties of fluorinated organic molecules make them of interest in materials science, and 5-Fluoro-2-methoxyaniline can serve as a precursor for advanced materials.
Research and Development
As a versatile building block, 5-Fluoro-2-methoxyaniline is utilised in academic and industrial research laboratories for exploring new synthetic routes and developing novel chemical entities.
| Molecular weight | 141.14 |
|---|---|
| Empirical formula | C7H8FNO |
| Assay | 97% |
| Boiling point | 90 °C/760 mmHg |
| Density | 1.1981 g/mL at 25 °C |
| Refractive index | n20/D 1.5438 |

Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 108 °C / 226.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Fluoro-2-methoxyaniline used for?
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5-Fluoro-2-methoxyaniline is primarily used as a building block in organic synthesis, particularly for the development of pharmaceuticals, agrochemicals, and advanced materials. It is also widely used in research and development laboratories.
What are the CAS number and chemical formula for 5-Fluoro-2-methoxyaniline?
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The CAS number for 5-Fluoro-2-methoxyaniline is 1978-39-8, and its chemical formula is C7H8FNO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Fluoro-2-methoxyaniline with a purity of 97%. We do not represent this product as USP, BP, or EP grade.
What are the primary safety concerns when handling 5-Fluoro-2-methoxyaniline?
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5-Fluoro-2-methoxyaniline is classified with GHS07 symbol and a Warning signal word. It carries hazard statements H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection, must be used. Ensure adequate ventilation and avoid inhalation of vapours or dust.
How is 5-Fluoro-2-methoxyaniline packed, shipped, and exported?
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Tech Serve Solutions packs and ships 5-Fluoro-2-methoxyaniline in compliance with all relevant transport regulations for hazardous materials. We are a specialist global supplier and exporter, experienced in international logistics.
How can I request a sample or a quote for 5-Fluoro-2-methoxyaniline?
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To request a sample or a quote, please contact our sales department through the website or by phone. Our team will be pleased to assist you with your requirements.
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