5′-Fluoro-2′-hydroxyacetophenone
5′-Fluoro-2′-hydroxyacetophenone (CAS 394-32-1) is a fluorinated organic building block with the molecular formula FC<sub>6</sub>H<sub>3</sub>(OH)COCH<sub>3</sub> and a molecular weight of 154.14 g/mol. This ketone is valuable in organic synthesis, particularly for the preparation of various heterocyclic compounds and complex organic molecules. Its structure incorporates both a hydroxyl group and a fluorine atom, offering diverse reactivity for further chemical transformations in research and development.
Synthesis of Flavonoids
5′-Fluoro-2′-hydroxyacetophenone serves as a key intermediate in the synthesis of 3-hydroxy and 3-methoxyflavones, contributing to the development of biologically active compounds.
Preparation of Chromones
It is utilised in the preparation of 3-hydroxy and 3-methoxy 2-styrylchromones, important heterocyclic structures with potential pharmaceutical applications.
Intermediate for Pentadienone Derivatives
The compound is employed in the synthesis of complex molecules such as 1-(5-fluoro-2-hydroxyphenyl)-3-hydroxy-5-phenyl-2,4-pentadien-1-one, expanding its utility in advanced organic chemistry.
| Molecular weight | 154.14 |
|---|---|
| Linear formula | FC6H3(OH)COCH3 |
| Assay | 98% |
| Boiling point | 65-66 °C/8 mmHg(lit.) |
| Application | 5′-Fluoro-2′-hydroxyacetophenone has been used in the preparation of:• 1-(5-fluoro-2-hydroxyphenyl)-3-hydroxy-5-phenyl-2,4-pentadien-1-one1• 3-hydroxy and 3-methoxyflavones1• 3-hydroxy and 3-methoxy 2-styrylchromones1 |
| Melting point | 56-58 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5′-Fluoro-2′-hydroxyacetophenone used for?
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5′-Fluoro-2′-hydroxyacetophenone is used as a building block in organic synthesis for preparing compounds such as 1-(5-fluoro-2-hydroxyphenyl)-3-hydroxy-5-phenyl-2,4-pentadien-1-one, 3-hydroxy and 3-methoxyflavones, and 3-hydroxy and 3-methoxy 2-styrylchromones.
What is the CAS number and molecular formula for 5′-Fluoro-2′-hydroxyacetophenone?
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The CAS number is 394-32-1 and the molecular formula is FC<sub>6</sub>H<sub>3</sub>(OH)COCH<sub>3</sub>.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5′-Fluoro-2′-hydroxyacetophenone with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 5′-Fluoro-2′-hydroxyacetophenone be handled safely?
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This compound is a warning substance that causes skin irritation, serious eye irritation, and respiratory irritation (H315, H319, H335) and is harmful if swallowed (H302). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 dust mask, in a well-ventilated area.
Is 5′-Fluoro-2′-hydroxyacetophenone a controlled substance?
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Based on the provided data, 5′-Fluoro-2′-hydroxyacetophenone is not listed as a controlled substance.
How is 5′-Fluoro-2′-hydroxyacetophenone packed, shipped, and exported?
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Tech Serve Solutions packages chemicals securely for transport and exports globally. Specific packaging details are available upon request.
How can I request a quote or sample for 5′-Fluoro-2′-hydroxyacetophenone?
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To request a quote or a sample of 5′-Fluoro-2′-hydroxyacetophenone, please contact our sales department through the website or by phone.
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