5-Chloro-2-(methylthio)pyrimidine
5-Chloro-2-(methylthio)pyrimidine (CAS: 38275-42-2; Formula: C5H5ClN2S; Molar Mass: 160.62 g/mol) is a halogenated heterocyclic compound. It serves as a versatile building block in organic synthesis, particularly for constructing more complex pyrimidine derivatives. This compound is essential in the chemical synthesis of advanced materials and active pharmaceutical ingredients, offering a reliable starting point for novel molecular architectures. Its specific reactivity makes it a valuable reagent for research and development in various chemical fields.

Organic Synthesis Intermediate
Utilised as a key intermediate in the synthesis of diverse organic molecules. It provides a pyrimidine scaffold functionalised with both chlorine and methylthio groups, enabling various coupling and substitution reactions.
Pharmaceutical Research
Serves as a building block in the development of potential pharmaceutical compounds. Its structural features can be incorporated into molecules designed for therapeutic applications.
Material Science Precursor
A precursor for synthesising novel materials with specific electronic or structural properties. The heterocyclic nature and functional groups allow for tailored molecular design.
| Molecular weight | 160.62 |
|---|---|
| Empirical formula | C5H5ClN2S |
| Assay | 97% |
| Melting point | 59-64 °C |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 1759 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Chloro-2-(methylthio)pyrimidine used for?
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5-Chloro-2-(methylthio)pyrimidine is primarily used as a building block and intermediate in organic synthesis, particularly for creating complex pyrimidine derivatives relevant to pharmaceutical research and material science.
What are the CAS number and formula for 5-Chloro-2-(methylthio)pyrimidine?
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The CAS number is 38275-42-2, and the empirical formula is C5H5ClN2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Chloro-2-(methylthio)pyrimidine with an assay of 97%. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
What are the primary safety concerns when handling 5-Chloro-2-(methylthio)pyrimidine?
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This compound is classified as Danger, indicated by GHS05 symbol and hazard statement H314, meaning it causes severe skin burns and eye damage. Appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respiratory protection, must be used. Emergency procedures should be readily available.
How is 5-Chloro-2-(methylthio)pyrimidine typically packed and exported?
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As per UN 1759 (Corrosive solid, n.o.s.) with Packing Group II, this product is handled with appropriate packaging for international transport, adhering to ADR regulations. Tech Serve Solutions is a global supplier and exporter of fine chemicals.
How can I request a quote or sample for 5-Chloro-2-(methylthio)pyrimidine?
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To request a quote or a sample, please contact our sales department via the website or direct email, providing your specific requirements and contact details.
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