5-Chloro-2-methoxypyridine
5-Chloro-2-methoxypyridine (CAS: 13473-01-3), with the molecular formula C6H6ClNO and a molecular weight of 143.57 g/mol, is a halogenated pyridine derivative. It serves as a versatile building block in organic synthesis. Its primary applications lie in its role as a reactant for palladium-catalyzed cross-coupling reactions, enabling the formation of complex biaryl structures and substituted pyridines.
Preparation of Biaryls
Utilised as a reactant in palladium-catalyzed Hiyama cross-coupling reactions with aryltrifluorosilanes, facilitating the synthesis of diverse biaryl compounds.
Suzuki-Miyaura Cross-Coupling
Employed as a key substrate in Suzuki-Miyaura cross-coupling reactions for constructing carbon-carbon bonds, leading to the synthesis of substituted aromatic systems.
Heterocyclic Synthesis
Acts as a valuable building block in the synthesis of various heterocyclic compounds, particularly those containing a pyridine core functionalised with chloro and methoxy groups.
| Molecular weight | 143.57 |
|---|---|
| Empirical formula | C6H6ClNO |
| Assay | 97% |
| Boiling point | 181-182 °C(lit.) |
| Density | 1.193 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5260(lit.) |
| Application | Reactant for:• Preparation of biaryls via palladium-catalyzed Hiyama cross-coupling with aryltrifluorosilanes1• Suzuki-Miyaura cross-coupling reactions2,3,4 |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 53 °C / 127.4 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-22-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Chloro-2-methoxypyridine used for?
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5-Chloro-2-methoxypyridine is primarily used as a reactant in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Hiyama couplings, for the preparation of biaryls and other complex organic molecules.
What is the CAS number and molecular formula for 5-Chloro-2-methoxypyridine?
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The CAS number is 13473-01-3, and the molecular formula is C6H6ClNO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Chloro-2-methoxypyridine with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should 5-Chloro-2-methoxypyridine be handled safely?
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5-Chloro-2-methoxypyridine is a flammable liquid and vapour (H226) and harmful if swallowed (H302), causing serious eye damage (H318). Handle with appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respiratory protection. Ensure adequate ventilation and keep away from heat and open flames.
Is 5-Chloro-2-methoxypyridine available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 5-Chloro-2-methoxypyridine.
How can I request a sample or quote for 5-Chloro-2-methoxypyridine?
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To request a sample or a quote, please contact our sales department through the website or by calling us. Please reference the product name and CAS number (13473-01-3).
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