5-Bromo-2′-deoxyuridine
5-Bromo-2′-deoxyuridine (CAS: 59-14-3) is a synthetic nucleoside analogue with the molecular formula C9H11BrN2O5. This brominated derivative of deoxyuridine is primarily utilised as a research tool in chemical biology and nucleoside chemistry. It serves as a valuable reagent in studies involving DNA synthesis and repair mechanisms, and finds application in cell proliferation assays.
- IUPAC
- 5-BrdU,5-Bromo-1-(2-deoxy-β-D-ribofuranosyl)uracil,5-Bromouracil deoxyriboside,BUdR
- Synonyms
- 5-BrdU5-Bromo-1-(2-deoxy-β-D-ribofuranosyl)uracil5-Bromouracil deoxyribosideBUdR
Chemical Biology Research
5-Bromo-2′-deoxyuridine is employed in various chemical biology applications, particularly for studying DNA synthesis and cellular processes. It can be incorporated into newly synthesised DNA, allowing for its detection and analysis.
Nucleoside Chemistry
As a derivative of deoxyuridine, this compound is a useful building block in nucleoside chemistry. It is utilised in the synthesis of modified nucleosides and nucleotides for research purposes.
Cell Proliferation Assays
Its ability to incorporate into DNA makes 5-Bromo-2′-deoxyuridine a key reagent for assessing cell proliferation and DNA replication rates in research settings.
| Molecular weight | 307.10 |
|---|---|
| Empirical formula | C9H11BrN2O5 |
| Assay | 97% |
| Solubility | NH4OH: soluble0.1 M at 20 °C, clear, colorless |
| Optical activity | [α]22/D +23.0°, c = 1 in H2O |
| Storage temperature | −20°C |
| Impurities tested | ≤0.005% Phosphorus (P)≤0.1% Insoluble matter |
| Melting point | 191-194 °C (dec.)(lit.) |
Hazard statements
- H340May cause genetic defects
- H361Suspected of damaging fertility or the unborn child
Precautionary statements
- P201Obtain special instructions before use
- P281Use personal protective equipment as required
- P308IF exposed or concerned
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | T |
| Risk statements (R) | 46-61 |
| Safety statements (S) | 53-45 |
| Cation traces | Al: ≤0.0005%Ca: ≤0.01%Cu: ≤0.0005%Fe: ≤0.0005%K: ≤0.005%Mg: ≤0.0005%NH4+: ≤0.05%Na: ≤0.05%Pb: ≤0.001%Zn: ≤0.0005% |
| Ignition residue | ≤0.1% |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Bromo-2′-deoxyuridine used for?
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5-Bromo-2′-deoxyuridine is primarily used in chemical biology for research, particularly in studies of DNA synthesis, repair, and cell proliferation. It serves as a nucleoside analogue and a building block in nucleoside chemistry.
What is the CAS number and formula for 5-Bromo-2′-deoxyuridine?
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The CAS number for 5-Bromo-2′-deoxyuridine is 59-14-3, and its molecular formula is C9H11BrN2O5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Bromo-2′-deoxyuridine with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling considerations for 5-Bromo-2′-deoxyuridine?
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5-Bromo-2′-deoxyuridine is classified as a Danger hazard (GHS08), with hazard statements H340 (May cause genetic defects) and H361 (Suspected of damaging fertility or the unborn child). Appropriate personal protective equipment, including eyeshields, gloves, and a P1 respirator filter, should be used. Handle with extreme caution.
How is 5-Bromo-2′-deoxyuridine packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports fine chemicals with rigorous adherence to international safety and regulatory standards. Specific packaging and shipping details are available upon request.
How can I request a quote or sample of 5-Bromo-2′-deoxyuridine?
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To request a quote or a sample of 5-Bromo-2′-deoxyuridine, please contact our sales department through our website or via the provided contact information.
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