5-Aza-2′-deoxycytidine
5-Aza-2′-deoxycytidine (CAS: 2353-33-5; C8H12N4O4) is a nucleoside analogue with significant biological activity. It functions as a potent DNA methyltransferase inhibitor, impacting gene expression and cellular processes. Primarily recognised for its role in cancer research and as an approved therapeutic candidate, this compound is vital for studies in epigenetics, cell biology, and oncology.
- IUPAC
- 2′-Deoxy-5-azacytidine,4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one,Decitabine
- Synonyms
- Decitabine
Cancer Research
5-Aza-2′-deoxycytidine is a key research chemical for investigating novel cancer therapies. Its mechanism of action involves DNA hypomethylation, which can reactivate tumor suppressor genes.
Epigenetic Studies
This compound is widely used to study DNA methylation and its role in gene regulation and expression. Researchers utilise it to probe the effects of epigenetic modifications on cellular function.
Drug Development
As an approved therapeutic candidate and a well-established antitumor agent, 5-Aza-2′-deoxycytidine serves as a reference compound or starting point in the development of new drugs targeting various diseases.
Cell Biology Research
It is employed in cell biology to understand the impact of DNA methylation changes on cellular pathways, differentiation, and development.
| Molecular weight | 228.21 |
|---|---|
| Empirical formula | C8H12N4O4 |
| Assay | ≥97% |
| Solubility | acetic acid: water (1:1): soluble50 mg/mL |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H341Suspected of causing genetic defects
- H360May damage fertility or the unborn child
Precautionary statements
- P201Obtain special instructions before use
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
- P308IF exposed or concerned
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 61-22-36/37/38-68 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Aza-2′-deoxycytidine used for?
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5-Aza-2′-deoxycytidine is used in cancer research, epigenetic studies, and drug development due to its DNA methyltransferase inhibitory properties. It is also an approved therapeutic candidate and antitumor agent.
What are the CAS number and molecular formula of 5-Aza-2′-deoxycytidine?
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The CAS number for 5-Aza-2′-deoxycytidine is 2353-33-5, and its molecular formula is C8H12N4O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Aza-2′-deoxycytidine with an assay of ≥97%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated.
How should 5-Aza-2′-deoxycytidine be handled safely?
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Handling 5-Aza-2′-deoxycytidine requires caution due to its potential hazards. It is harmful if swallowed, causes skin and eye irritation, and may cause respiratory irritation. It is also suspected of causing genetic defects and may damage fertility or the unborn child. Use appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, in a well-ventilated area.
Is 5-Aza-2′-deoxycytidine a controlled substance?
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The provided data does not indicate that 5-Aza-2′-deoxycytidine is a controlled substance. However, users should verify local regulations.
How can I request a sample or quote for 5-Aza-2′-deoxycytidine?
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To request a sample or a quote, please contact our sales team through the website or by phone. We export globally and can assist with your specific requirements.
What is the molecular weight of 5-Aza-2′-deoxycytidine?
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The molecular weight of 5-Aza-2′-deoxycytidine is 228.21 g/mol.
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