(4R,5R)-2-Chloro-3,4-dimethyl-2,5-diphenyl-1-oxa-3-aza-2-silacyclopentane
(4R,5R)-2-Chloro-3,4-dimethyl-2,5-diphenyl-1-oxa-3-aza-2-silacyclopentane (CAS: 1236123-69-5) is a chiral silacyclopentane derivative with a molecular weight of 303.86 g/mol. This compound is recognised for its utility as a powerful enantioselective reagent in asymmetric synthesis, particularly in carbonyl and imine addition reactions. Its strained ring structure contributes to its reactivity, making it valuable in sophisticated chemical synthesis pathways.
- IUPAC
- (1R,2R)-Pseudoephedrine phenylchlorosilane,(4R,5R)-2-Chloro-3,4-dimethyl-2,5-diphenyl-1,3,2-oxazasilolidine
- Synonyms
- (4R,5R)-2-Chloro-3,4-dimethyl-2,5-diphenyl-1,3,2-oxazasilolidine5-diphenyl-1-oxa-3-aza-2-silacyclopentane
Asymmetric Synthesis
This compound serves as a key reagent in asymmetric synthesis, enabling the creation of chiral molecules with high enantiomeric purity. It is particularly effective in catalytic applications, promoting stereoselective transformations.
Carbonyl and Imine Additions
It is employed in the enantioselective addition of nucleophiles to carbonyl and imine functionalities. This application is crucial for constructing complex organic molecules with specific stereochemistry.
Chiral Catalysis
As a chiral catalyst or ligand precursor, it facilitates stereoselective reactions, contributing to the development of efficient synthetic routes for pharmaceuticals and fine chemicals.
Chemical Synthesis
This reagent is a versatile tool for general chemical synthesis, offering unique reactivity due to its strained silacyclopentane structure.
| Molecular weight | 303.86 |
|---|---|
| Empirical formula | C16H18ClNOSi |
| Assay | 97% |
| Density | 1.151 g/mL at 25 °C |
| Application | Leighton’s Strained Silacycles: Powerful Enantioselective Allylation Reagents |
| Flash point | >110 °C / >230 °F |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (4R,5R)-2-Chloro-3,4-dimethyl-2,5-diphenyl-1-oxa-3-aza-2-silacyclopentane used for?
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This compound is primarily used as a reagent in asymmetric synthesis, specifically for enantioselective addition reactions to carbonyl and imine compounds. It is also valuable in chiral catalysis and general chemical synthesis.
What is the CAS number and formula for this chemical?
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The CAS number is 1236123-69-5, and its empirical formula (Hill notation) is C16H18ClNOSi.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical at a purity of 97%. This is a research-grade material, and TSS does not represent it as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling considerations?
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This compound has a flash point greater than 110 °C (>230 °F) and a WGK Germany rating of 3, indicating it is hazardous. Appropriate personal protective equipment should be used, and it should be handled in a well-ventilated area, following standard laboratory safety protocols for chemical reagents.
Can Tech Serve Solutions export this chemical?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents.
How can I request a sample or quote?
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To request a sample or quote for (4R,5R)-2-Chloro-3,4-dimethyl-2,5-diphenyl-1-oxa-3-aza-2-silacyclopentane, please contact our sales team through the website or by phone.
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