4-(Trifluoromethoxy)aniline
4-(Trifluoromethoxy)aniline (CAS: 461-82-5), with the chemical formula CF3OC6H4NH2 and a molecular weight of 177.12 g/mol, is a key organic building block. This aromatic amine features a trifluoromethoxy group, imparting unique electronic properties. It serves as a versatile intermediate in the synthesis of pharmaceuticals, agrochemicals, and advanced materials, facilitating the introduction of fluorinated moieties into complex molecules.
- IUPAC
- α,α,α-Trifluoro-p-anisidine
Pharmaceutical Intermediate
Utilised in the synthesis of active pharmaceutical ingredients (APIs), where the trifluoromethoxy group can enhance metabolic stability and lipophilicity. It is a precursor for various therapeutic agents.
Agrochemical Synthesis
Serves as a building block for novel pesticides and herbicides. The fluorinated substituent can improve the efficacy and environmental profile of agrochemical products.
Material Science
Incorporated into the development of specialised polymers and functional materials. Its unique structure can influence properties such as thermal stability and optical characteristics.
Organic Synthesis Reagent
A valuable reagent in organic chemistry laboratories for the construction of complex organic molecules. It participates in a range of coupling and substitution reactions.
| Molecular weight | 177.12 |
|---|---|
| Linear formula | CF3OC6H4NH2 |
| Assay | 98% |
| Boiling point | 73-75 °C/10 mmHg(lit.) |
| Density | 1.32 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.463(lit.) |
Hazard statements
- H301Toxic if swallowed
- H310Fatal in contact with skin
- H315Causes skin irritation
- H318Causes serious eye damage
- H373May cause damage to organs through prolonged exposure
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P302IF ON SKIN
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 81 °C / 177.8 °F |
| Transport (UN / ADR) | UN 2941 6.1 / PGIII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | T |
| Risk statements (R) | 24/25-33-38-41 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Trifluoromethoxy)aniline used for?
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4-(Trifluoromethoxy)aniline is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. It is a valuable building block in organic synthesis.
What is the CAS number and chemical formula for 4-(Trifluoromethoxy)aniline?
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The CAS number for 4-(Trifluoromethoxy)aniline is 461-82-5, and its chemical formula is CF3OC6H4NH2.
What grade and purity does Tech Serve Solutions supply for 4-(Trifluoromethoxy)aniline?
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Tech Serve Solutions supplies 4-(Trifluoromethoxy)aniline with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 4-(Trifluoromethoxy)aniline be handled safely?
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Handling requires strict safety precautions due to its hazardous nature. Refer to the Safety Data Sheet. Recommended PPE includes eyeshields, face shields, and appropriate respirator filters (e.g., ABEK). Avoid contact with skin and eyes. It is acutely toxic if swallowed or in contact with skin, and causes serious eye damage.
Is 4-(Trifluoromethoxy)aniline a controlled substance?
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The provided data does not indicate that 4-(Trifluoromethoxy)aniline is a controlled substance.
How is 4-(Trifluoromethoxy)aniline packed and shipped?
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As a global supplier and exporter, Tech Serve Solutions ensures secure and compliant packing for international shipment of chemicals like 4-(Trifluoromethoxy)aniline, adhering to all relevant transport regulations (e.g., UN 2941).
How can I request a sample or quote for 4-(Trifluoromethoxy)aniline?
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To request a sample or a quotation for 4-(Trifluoromethoxy)aniline, please contact our sales department through the website or by phone, providing your specific requirements.
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