4-Pyridinylboronic acid
4-Pyridinylboronic acid (CAS: 1692-15-5, C5H6BNO2) is a boronic acid derivative used as a reagent in organic synthesis. With a molecular weight of 122.92 g/mol, it is particularly valuable in palladium-catalyzed coupling reactions, such as the Suzuki-Miyaura coupling. Its applications extend to the preparation of complex molecules, including potential therapeutic agents like HIV-1 protease inhibitors and cancer therapeutics.
- IUPAC
- 4-Pyridineboronic acid,4-Pyridylboronic acid
- Synonyms
- 4-Pyridineboronic acid4-Pyridylboronic acid
Suzuki-Miyaura Coupling Reactions
4-Pyridinylboronic acid serves as a key building block in palladium-catalyzed Suzuki-Miyaura coupling reactions. It is also effective in ligand-free Suzuki coupling reactions under microwave irradiation, enabling efficient carbon-carbon bond formation.
Preparation of Pharmaceutical Intermediates
This compound is utilised in the synthesis of various pharmaceutical intermediates. Notably, it has been employed in the preparation of HIV-1 protease inhibitors, contributing to the development of antiviral therapies.
Synthesis of Potential Therapeutics
4-Pyridinylboronic acid is instrumental in the research and development of novel therapeutic agents. It has been used in the synthesis of potential inhibitors for targets such as PDK1 and protein kinase CK2, relevant in cancer research.
| Molecular weight | 122.92 |
|---|---|
| Empirical formula | C5H6BNO2 |
| Assay | 90% |
| Storage temperature | −20°C |
| Application | Reagent used for• Palladium-catalyzed Suzuki-Miyaura coupling reactions1 • Ligand-free palladium-catalyzed Suzuki coupling reaction under microwave irradation2 Reagent used in Preparation of • HIV-1 protease inhibitors3 • Potential cancer threapeutics, such as PDK1 and protein kinase CK2 inhibitors4,5 |
| Melting point | >300 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Pyridinylboronic acid used for?
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4-Pyridinylboronic acid is primarily used as a reagent in palladium-catalyzed Suzuki-Miyaura coupling reactions and in the preparation of pharmaceutical intermediates, including HIV-1 protease inhibitors and potential cancer therapeutics.
What is the CAS number and formula for 4-Pyridinylboronic acid?
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The CAS number is 1692-15-5 and the empirical formula is C5H6BNO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Pyridinylboronic acid with a minimum assay of 90%. This product is intended for research and laboratory use and is not represented as USP, BP, or EP grade.
How should 4-Pyridinylboronic acid be handled and stored?
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Due to its potential hazards, handle 4-Pyridinylboronic acid with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Store at -20°C.
Is 4-Pyridinylboronic acid a hazardous substance?
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Yes, 4-Pyridinylboronic acid is classified with a WGK rating of 3 in Germany, indicating it is hazardous to water. Always consult the Safety Data Sheet for comprehensive hazard information.
How is 4-Pyridinylboronic acid packed and shipped?
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4-Pyridinylboronic acid is carefully packed to ensure safe transit and is exported globally by Tech Serve Solutions, a specialist supplier since 1998.
How can I request a quote or sample of 4-Pyridinylboronic acid?
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To request a quote or a sample of 4-Pyridinylboronic acid, please contact the Tech Serve Solutions sales team through our website or by phone.
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