4-Phenylimidazole
4-Phenylimidazole (CAS: 670-95-1; Formula: C9H8N2) is a heterocyclic organic compound with a molecular weight of 144.17 g/mol. It serves as a valuable building block in chemical synthesis, particularly within the realm of heterocyclic chemistry. Its applications extend to biochemical research, including the investigation of protein-ligand interactions and as a heme ligand in enzyme crystallisation studies. Available with an assay of 97%, it is suitable for various research and synthetic purposes.
Protein-Ligand Interaction Studies
4-Phenylimidazole has been employed to investigate protein-ligand interactions, specifically in the context of cytochrome P450 from the thermoacidophile organism *Picrophilus torridus*. This research aids in understanding enzyme mechanisms and drug interactions.
Enzyme Crystallography
It functions as a heme ligand during the crystallisation of enzymes such as recombinant human indoleamine 2,3-dioxygenase. This application is crucial for determining the three-dimensional structure of enzymes.
Coordination Chemistry
4-Phenylimidazole is utilised in the synthesis of coordination complexes involving transition metals like copper and cobalt. These complexes can have diverse applications in catalysis and materials science.
| Molecular weight | 144.17 |
|---|---|
| Empirical formula | C9H8N2 |
| Assay | 97% |
| Solubility | acetone: soluble25 mg/mL, clear, colorless to yellow (typical) |
| Application | 4-Phenylimidazole was used to investigate the protein-ligand interactions in cytochrome P450 from the thermoacidophile Picrophilus torridus1. It was used as heme ligand during the crystallization of recombinant human indoleamine 2,3-dioxygenase2. It was used in the synthesis of complexes of copper and cobalt3. |
| Melting point | 128-131 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Phenylimidazole used for?
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4-Phenylimidazole is used in chemical synthesis as a building block, for investigating protein-ligand interactions, as a heme ligand in enzyme crystallography, and in the synthesis of metal complexes.
What are the CAS number and formula for 4-Phenylimidazole?
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The CAS number for 4-Phenylimidazole is 670-95-1, and its empirical formula is C9H8N2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Phenylimidazole with a minimum assay of 97%. This product is typically supplied for research and laboratory use and is not represented as USP, BP, EP, or pharmacopoeia grade.
How should 4-Phenylimidazole be handled?
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Handle 4-Phenylimidazole with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Ensure adequate ventilation and avoid inhalation of dust, skin contact, and eye contact, as it may cause skin irritation, eye irritation, and respiratory irritation.
Is 4-Phenylimidazole a controlled substance?
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Based on the provided data, 4-Phenylimidazole is not indicated as a controlled substance. However, users should always verify local regulations.
How is 4-Phenylimidazole shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and 4-Phenylimidazole is available for export worldwide, adhering to all relevant shipping and safety regulations.
How can I request a sample or quote for 4-Phenylimidazole?
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To request a sample or obtain a quote for 4-Phenylimidazole, please contact our sales team through the TSS website or by calling our dedicated customer service line.
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