4-Nitrobenzyl chloroformate
4-Nitrobenzyl chloroformate (CAS 737-12-2) is a reactive organic compound with the linear formula ClCO2CH2C6H4NO2 and a molecular weight of 215.59 g/mol. It functions as a valuable reagent in chemical synthesis, particularly for introducing the 4-nitrobenzyloxycarbonyl (Z) protecting group. This protection strategy is widely employed in peptide chemistry and the synthesis of complex organic molecules.
Peptide Synthesis
4-Nitrobenzyl chloroformate is used to introduce the 4-nitrobenzyloxycarbonyl (Z) protecting group onto amino acids. This group is stable under various reaction conditions and can be selectively removed, facilitating stepwise peptide chain elongation.
Organic Synthesis Reagent
As a versatile chloroformate ester, it serves as an electrophilic building block in organic synthesis. It is employed for derivatization and the construction of more complex molecular architectures.
Chemical Biology Research
Its utility extends to chemical biology, where it can be used in the synthesis of modified biomolecules or as a reagent in probing biological pathways.
| Molecular weight | 215.59 |
|---|---|
| Linear formula | ClCO2CH2C6H4NO2 |
| Assay | 97% |
| Storage temperature | 2-8°C |
| Melting point | 32-34 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-37 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Nitrobenzyl chloroformate used for?
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4-Nitrobenzyl chloroformate is primarily used in organic synthesis, especially in peptide chemistry, for introducing the 4-nitrobenzyloxycarbonyl (Z) protecting group onto amino acids.
What are the CAS number and formula for 4-Nitrobenzyl chloroformate?
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The CAS number is 4457-32-3 and the linear formula is ClCO2CH2C6H4NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Nitrobenzyl chloroformate with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
What are the safety considerations when handling 4-Nitrobenzyl chloroformate?
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4-Nitrobenzyl chloroformate is classified as Danger with hazard statement H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and respiratory protection, is essential. Always consult the Safety Data Sheet (SDS) before handling.
How is 4-Nitrobenzyl chloroformate shipped?
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It is shipped as a UN 3261, Class 8, Packing Group II hazardous material.
How can I request a quote or sample?
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Please contact our sales team directly through the website to request a quote or sample of 4-Nitrobenzyl chloroformate.
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