4-Nitrobenzyl chloride
4-Nitrobenzyl chloride (CAS: 100-14-1), with the molecular formula O2NC6H4CH2Cl and a molecular weight of 171.58 g/mol, is a vital organic building block. This nitro compound is primarily used in chemical synthesis, notably for preparing complex ether derivatives like unsymmetrically substituted diaza-crown-ether compounds. Its defined purity and properties make it a reliable reagent for advanced organic chemistry applications.
- IUPAC
- α-Chloro-4-nitrotoluene
Intermediate in Organic Synthesis
4-Nitrobenzyl chloride serves as a key intermediate in the synthesis of various organic compounds. It is particularly useful for introducing the 4-nitrobenzyl moiety into molecular structures.
Preparation of Crown Ether Derivatives
This compound has been utilised in the preparation of unsymmetrically N,N′-bis(substituted) 4,13-diaza-18-crown-6-ether derivatives, showcasing its utility in creating complex macrocyclic structures.
Reagent for Chemical Synthesis
As a nitro compound and organic building block, 4-Nitrobenzyl chloride is a versatile reagent in academic and industrial research laboratories for diverse synthetic transformations.
| Molecular weight | 171.58 |
|---|---|
| Linear formula | O2NC6H4CH2Cl |
| Assay | 99% |
| Solubility | chloroform: soluble50 mg/mL, clear to very slightly hazy, faintly yellow |
| Application | 4-Nitrobenzyl chloride was used to prepare unsymmetrically N,N′-bis(substituted) 4,13-diaza-18-crown-6-ether derivatives.1 |
| Melting point | 70-73 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 22-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Nitrobenzyl chloride used for?
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4-Nitrobenzyl chloride is primarily used as a building block in organic synthesis, including the preparation of specific crown ether derivatives. It is a versatile reagent for introducing the 4-nitrobenzyl group.
What is the CAS number and formula for 4-Nitrobenzyl chloride?
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The CAS number for 4-Nitrobenzyl chloride is 100-14-1, and its linear formula is O2NC6H4CH2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Nitrobenzyl chloride with a minimum assay of 99%. We do not represent this product as USP, BP, or EP grade.
What are the main safety hazards associated with 4-Nitrobenzyl chloride?
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4-Nitrobenzyl chloride is classified as corrosive and harmful if swallowed (H302-H314). It requires careful handling with appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, to avoid skin burns, eye damage, and respiratory irritation.
How is 4-Nitrobenzyl chloride packed and shipped?
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4-Nitrobenzyl chloride is shipped as UN 3261, Class 8, Packing Group II, indicating it is a corrosive solid, acid, or base, solid, n.o.s. TSS ensures compliant packaging for export.
How can I request a quote or sample of 4-Nitrobenzyl chloride?
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To request a quote or sample of 4-Nitrobenzyl chloride, please contact the TSS sales team through our website or by phone.
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