4-Methyl-3-(trifluoromethyl)phenyl isothiocyanate
4-Methyl-3-(trifluoromethyl)phenyl isothiocyanate (CAS: 351003-67-3) is a specialized organic compound with the molecular formula C6H3CH3CF3NCS and a molecular weight of 217.21 g/mol. This trifluoromethylated phenyl isothiocyanate serves as a valuable building block in organic synthesis. It is commonly employed in the development of novel chemical entities and intermediates within research and industrial settings, particularly in areas requiring specific sulfur and fluorine functionalities.
Organic Synthesis Intermediate
This compound functions as a key intermediate in multi-step organic syntheses. Its reactive isothiocyanate group allows for facile derivatization into various heterocyclic systems and functionalised molecules.
Chemical Research and Development
Utilised in R&D laboratories for the exploration of new chemical pathways and the synthesis of novel compounds. Its unique structural features, including the trifluoromethyl group, are of interest in medicinal chemistry and materials science.
Building Block for Specialty Chemicals
Serves as a versatile building block for the creation of more complex specialty chemicals. The trifluoromethyl and isothiocyanate moieties offer distinct reactivity profiles for targeted synthesis.
| Molecular weight | 217.21 |
|---|---|
| Linear formula | C6H3CH3CF3NCS |
| Assay | 98% |
| Boiling point | 208 °C(lit.) |
| Density | 1.291 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5635(lit.) |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P342
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 57 °C / 134.6 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38-42 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Methyl-3-(trifluoromethyl)phenyl isothiocyanate used for?
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This compound is primarily used as a building block in organic synthesis and in chemical research and development for creating novel chemical entities and intermediates.
What is the CAS number and molecular formula?
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The CAS number is 351003-67-3 and the molecular formula is C6H3CH3CF3NCS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 98%. We do not represent it as USP, BP, or EP grade; it is suitable for research and technical applications.
How should 4-Methyl-3-(trifluoromethyl)phenyl isothiocyanate be handled?
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This compound is classified as dangerous. It is flammable (flash point 57 °C), harmful if swallowed, in contact with skin, or if inhaled, and causes skin and serious eye irritation, and may cause respiratory irritation. Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area. Refer to the Safety Data Sheet for full handling procedures.
How is this chemical exported?
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Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents, adhering to all necessary shipping and regulatory requirements.
How can I request a sample or quote?
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Please contact our sales team through the website or by phone to request a sample or a detailed quotation for 4-Methyl-3-(trifluoromethyl)phenyl isothiocyanate.
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