4-Methoxyphenylboronic acid

CAS 5720-07-0CH3OC6H4B(OH)2Chemical Synthesis

4-Methoxyphenylboronic acid (CAS: 5720-07-0), with the molecular formula CH3OC6H4B(OH)2 and a molecular weight of 151.96, is a crucial organoboron compound. It functions as a versatile reagent in organic synthesis, primarily recognised for its utility in various palladium-catalyzed cross-coupling reactions. This compound is essential for building complex molecular architectures in academic research and industrial chemical processes.

IUPAC: (4-Methoxyphenyl)boric acid,(p-Methoxyphenyl)boronic acid,4-Methoxybenzeneboronic acid,4-Anisylboronic acid,p-Methoxybenzeneboronic acid,p-Anisylboronic acid
Synonyms: (4-Methoxyphenyl)boronic acid(p-Methoxyphenyl)boronic acid4-Methoxybenzeneboronic acid4-Anisylboronic acidp-Methoxybenzeneboronic acidp-Anisylboronic acid

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4-Methoxyphenylboronic acid (CH3OC6H4B(OH)2) — chemical structure, CAS 5720-07-0; Chemistry, fine chemical supplied by Tech Serve Solutions

Aryl Boronic AcidsBoronic AcidsChemical Synthesis

01 /Applications

Suzuki-Miyaura Cross-Coupling

4-Methoxyphenylboronic acid is a widely used substrate in Suzuki-Miyaura cross-coupling reactions. This palladium-catalyzed process enables the formation of carbon-carbon bonds, facilitating the synthesis of biaryl compounds and other complex organic molecules.

Palladium-Catalyzed Direct Arylation

This boronic acid serves as a key reagent in palladium-catalyzed direct arylation reactions. These methods allow for the direct functionalization of C-H bonds, offering an efficient route to substituted aromatic compounds.

Preparation of Catalysts and Chromophores

It is employed in the preparation of advanced materials, including palladium(II) thiocarboxamide complexes used as Suzuki coupling catalysts and for the synthesis of push-pull arylvinyldiazine chromophores.

Copper-Mediated and Catalyzed Reactions

4-Methoxyphenylboronic acid participates in copper-mediated reactions, such as ligandless aerobic fluoroalkylation, and is utilized in various copper-catalyzed coupling processes, contributing to diverse synthetic strategies.

02 /Properties

Molecular weight	151.96
Linear formula	CH3OC6H4B(OH)2
Assay	≥95% (TLC)
Application	Reagent used for• Suzuki-Miyaura cross-coupling reactions1 • Pd-catalyzed direct arylation2 • Highly effective synthesis using palladium-catalyzed arylation Suzuki-Miyaura cross-coupling in water3 • Palladium-catalyzed stereoselective Heck-type reaction4 • Tandem-type Pd(II)-catalyzed oxidative Heck reaction and intramolecular C-H amidation sequence5 • Copper-mediated ligandless aerobic fluoroalkylation of arylboronic acids with fluoroalkyl iodides6 • Ruthenium catalyzed direct arylation7 • Rh-catalyzed asymmetric conjugate addition8 • Ligand-free copper-catalyzed coupling9 Reagent used in Preparation of• Palladium(II) thiocarboxamide complexes as Suzuki coupling catalyst10 • Push-pull arylvinyldiazine chrom
Melting point	204-206 °C(lit.)209-212 °C

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

5720-07-0

MDL number

MFCD00039139

PubChem substance

24866163

Beilstein registry

2936912

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 4-Methoxyphenylboronic acid used for?

4-Methoxyphenylboronic acid is a reagent used in Suzuki-Miyaura cross-coupling reactions, palladium-catalyzed direct arylation, and in the preparation of various catalysts and chromophores. It is also used in copper-mediated and catalyzed reactions.

What is the CAS number and chemical formula for 4-Methoxyphenylboronic acid?

The CAS number is 5720-07-0, and the linear chemical formula is CH3OC6H4B(OH)2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 4-Methoxyphenylboronic acid with a minimum purity of ≥95% (TLC). This product is supplied for research and development purposes and is not intended for USP, BP, EP, or any pharmacopoeia, nutraceutical, or food applications.

What are the safety precautions when handling 4-Methoxyphenylboronic acid?

4-Methoxyphenylboronic acid is classified with GHS07 symbol and a Warning signal word, with hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area and avoid dust formation.

How is 4-Methoxyphenylboronic acid packed, shipped, and exported?

Tech Serve Solutions ensures that 4-Methoxyphenylboronic acid is packed securely for transport. We are a specialist global supplier and exporter of fine chemicals, adhering to all relevant shipping and export regulations for chemical products.

How can I request a sample or a quote for 4-Methoxyphenylboronic acid?

To request a sample or a quote for 4-Methoxyphenylboronic acid, please visit our website or contact our sales team directly. Provide the product name and CAS number (5720-07-0) for prompt service.