4-Isopropylphenylzinc iodide solution
4-Isopropylphenylzinc iodide solution (CAS 308796-20-5) with a molecular weight of 311.48 g/mol, is a valuable organozinc reagent. Supplied as a 0.5 M solution in Tetrahydrofuran (THF), this compound is characterised by its reactivity in organic synthesis. It serves as a key building block and intermediate in the formation of carbon-carbon bonds, particularly through cross-coupling reactions, facilitating the synthesis of complex organic molecules.
Organozinc Reagent in Cross-Coupling Reactions
This organozinc iodide is extensively employed in palladium-catalysed cross-coupling reactions, such as Negishi couplings. It enables the efficient formation of C-C bonds by coupling with aryl or vinyl halides and pseudohalides.
Synthesis of Functionalised Aromatic Compounds
It acts as a nucleophilic source of the 4-isopropylphenyl group, allowing for the introduction of this moiety into various organic frameworks. This is crucial for the synthesis of diverse aromatic compounds with specific substitution patterns.
Intermediate in Pharmaceutical Synthesis
The compound serves as a versatile intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs) and complex drug candidates where precise aryl group introduction is required.
Research and Development in Organic Chemistry
Utilised in academic and industrial research laboratories for exploring new synthetic methodologies and developing novel organic molecules with potential applications in materials science and medicinal chemistry.
| Molecular weight | 311.48 |
|---|---|
| Linear formula | (CH3)2CHC6H4Znl |
| Boiling point | 65 °C |
| Density | 0.997 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-14-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Isopropylphenylzinc iodide solution used for?
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4-Isopropylphenylzinc iodide solution (CAS 308796-20-5) is primarily used as an organozinc reagent in organic synthesis, particularly for cross-coupling reactions like the Negishi coupling, and for introducing the 4-isopropylphenyl group into organic molecules.
What are the CAS number and formula for 4-Isopropylphenylzinc iodide solution?
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The CAS number is 308796-20-5. The linear formula is (CH3)2CHC6H4ZnI.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Isopropylphenylzinc iodide solution at a concentration of 0.5 M in THF. This product is intended for research and chemical synthesis purposes and is not represented as USP, BP, EP, or any other pharmacopoeial grade.
What are the key safety hazards associated with this product?
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This solution is highly flammable (H225), causes serious eye irritation (H319), and may cause respiratory irritation (H335). It is also suspected of causing cancer (H351) and may form explosive peroxides. Handle with extreme caution in a well-ventilated area, away from ignition sources.
How is this chemical packed, shipped, and exported?
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4-Isopropylphenylzinc iodide solution is packed and shipped according to stringent international regulations for hazardous materials, including UN 2924 classification. Tech Serve Solutions has extensive experience in exporting such chemicals globally.
How can I request a sample or a quote for 4-Isopropylphenylzinc iodide solution?
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To request a sample or a quote, please contact our sales team through the website or call us directly. Please specify the quantity and your intended application for our reference.
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