4′-Hydroxyacetophenone
4′-Hydroxyacetophenone (CAS: 99-93-4), a white to faintly yellow crystalline solid with the molecular formula C8H8O2 and a molar mass of 136.15 g/mol, is a versatile organic building block. It serves as a ketone component in Mannich reactions for synthesizing potential cytotoxic agents. Its applications span chemical synthesis, materials science, and polymer science, particularly as a reagent and initiator in polymerization processes.
- Synonyms
- 4-Hydroxyacetophenone4-Acetylphenolp-Hydroxyacetophenonep-AcetylphenolEthanone, 1-(4-hydroxyphenyl)-Phenol, p-acetyl-
Mannich Reactions
4′-Hydroxyacetophenone acts as a ketone substrate in Mannich reactions to prepare 1-aryl-3-phenethylamino-1-propanone hydrochlorides, which have been investigated for their cytotoxic potential.
Polymer Science
This compound functions as a building block and initiator in polymer chemistry. It is utilised as a reagent for polymerization and finds applications in polymer synthesis and materials science.
Organic Synthesis
As a valuable intermediate, 4′-Hydroxyacetophenone is employed in various organic synthesis pathways, contributing to the construction of more complex molecular structures.
| Molecular weight | 136.15 |
|---|---|
| Linear formula | HOC6H4COCH3 |
| Assay | 99% |
| Boiling point | 147-148 °C/3 mmHg(lit.) |
| Solubility | 95% ethanol: soluble5%, colorless to faintly yellow |
| Application | 4′-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions1. |
| Melting point | 109-111 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
| Safety statements (S) | 22-24/25 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4′-Hydroxyacetophenone used for?
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4′-Hydroxyacetophenone is used as a ketone component in Mannich reactions to synthesise potential cytotoxic agents, and as a building block, initiator, and reagent in polymer science and general organic synthesis.
What is the CAS number and formula for 4′-Hydroxyacetophenone?
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The CAS number for 4′-Hydroxyacetophenone is 99-93-4, and its linear formula is HOC6H4COCH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4′-Hydroxyacetophenone with a minimum assay of 99%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or pharmacopoeia grade.
How should 4′-Hydroxyacetophenone be handled safely?
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Handle 4′-Hydroxyacetophenone with appropriate personal protective equipment, including a dust mask (N95 US type), eyeshields, and gloves. Avoid inhaling dust. Refer to the Safety Data Sheet for comprehensive handling information.
Is 4′-Hydroxyacetophenone a controlled substance?
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Based on the provided data, 4′-Hydroxyacetophenone (CAS: 99-93-4) is not indicated as a controlled substance.
How is 4′-Hydroxyacetophenone packed and shipped?
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4′-Hydroxyacetophenone is carefully packed to ensure safe transit and is available for export globally by Tech Serve Solutions.
How can I request a sample or quote for 4′-Hydroxyacetophenone?
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To request a sample or a quote for 4′-Hydroxyacetophenone, please contact the Tech Serve Solutions sales team through our website or by calling our office.
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