4′-Hydroxy-3′-iodoacetophenone

CAS 62615-24-1C8H7IO2Chemical Synthesis

4′-Hydroxy-3′-iodoacetophenone (CAS: 62615-24-1, C8H7IO2) is a valuable organic building block with a molecular weight of 262.04 g/mol. Supplied by Tech Serve Solutions with a typical assay of 97%, this iodinated acetophenone derivative serves as a key intermediate in complex organic synthesis. Its structure lends itself to various palladium-catalyzed reactions, facilitating the construction of intricate heterocyclic and polycyclic systems, crucial in pharmaceutical and materials science research.

IUPAC: 1-(4-Hydroxy-3-iodophenyl)ethanone,2-Iodo-4-acetylphenol,3-Iodo-4-hydroxyacetophenone,4-Acetyl-2-iodophenol
Synonyms: 1-(4-Hydroxy-3-iodophenyl)ethanone2-Iodo-4-acetylphenol3-Iodo-4-hydroxyacetophenone4-Acetyl-2-iodophenol

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4′-Hydroxy-3′-iodoacetophenone (C8H7IO2) — chemical structure, CAS 62615-24-1; Chemistry, fine chemical supplied by Tech Serve Solutions

Building BlocksC7 to C8Carbonyl CompoundsChemical SynthesisKetones

01 /Applications

Heterocyclic Synthesis

This compound is a versatile reactant in palladium-catalyzed tandem reactions for preparing cyclopentene fused benzofurans and indoles with diazabicyclic alkenes. It also facilitates the regioselective synthesis of indene derivatives through Pd/C-catalyzed cyclization.

Spirocyclic and Polycyclic Compound Preparation

It is employed in the highly regioselective synthesis of spirocyclic compounds via palladium-catalyzed intermolecular tandem reactions. Furthermore, it enables the stereoselective preparation of heteropolycyclic compounds through palladium-catalyzed heteroannulation.

Carbazole and Coumarin Synthesis

4′-Hydroxy-3′-iodoacetophenone is used in the preparation of carbazoles via cross-coupling with silylaryl triflates followed by palladium-catalyzed cyclization. It is also a precursor for disubstituted coumarins via palladium-catalyzed carbonylative annulation of internal alkynes.

Arylalkyne, Benzofuran, and Indole Synthesis

This chemical serves as a starting material for the synthesis of arylalkynes, benzofurans, and indoles through Sonogashira coupling reactions followed by cyclization processes.

02 /Properties

Molecular weight	262.04
Empirical formula	C8H7IO2
Assay	97%
Application	Reactant for:• Preparation of cyclopentene fused benzofurans and indoles via Pd-catalyzed tandem ring opening-ring closing reaction with diazabicyclic alkenes1• Highly regioselective synthesis of spirocyclic compounds by a palladium-catalyzed intermolecular tandem reaction2• Regioselective synthesis of indene derivatives via Pd/C-catalyzed cyclization reaction in air3• Preparation of carbazoles via cross-coupling with silylaryl triflates followed by palladium-catalyzed cyclization4• Stereoselective preparation of heteropolycyclic compounds via palladium-catalyzed stereoselective heteroannulation of with cyclic alkenes5• Preparation of disubstituted coumarins via palladium-catalyzed carbonylative annulation of internal alkynes6• Preparation of arylalkynes, benzofurans and indoles via Sonogashira coupling and cyclizatio
Melting point	155-160 °C

03 /Safety & handling

GHS hazard pictogram: Corrosive (GHS05) — Corrosive

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Danger

Hazard statements

H302Harmful if swallowed
H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection
P305IF IN EYES

Water hazard class (WGK, DE)	1
Hazard codes (EU)	Xn
Risk statements (R)	22-41
Safety statements (S)	26-39

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

62615-24-1

MDL number

MFCD06200221

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 4′-Hydroxy-3′-iodoacetophenone used for?

4′-Hydroxy-3′-iodoacetophenone (CAS: 62615-24-1) is primarily used as a reactant and building block in organic synthesis, particularly for the preparation of various heterocyclic, spirocyclic, and polycyclic compounds through palladium-catalyzed reactions.

What are the CAS number and chemical formula?

The CAS number for 4′-Hydroxy-3′-iodoacetophenone is 62615-24-1, and its empirical formula is C8H7IO2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 4′-Hydroxy-3′-iodoacetophenone with a purity of at least 97%. This product is suitable for research and chemical synthesis; TSS does not represent it as USP, BP, or EP grade.

How should 4′-Hydroxy-3′-iodoacetophenone be handled safely?

Danger. This compound is harmful if swallowed (H302) and causes serious eye damage (H318). Wear protective gloves and eye protection (P280). In case of contact with eyes, rinse cautiously with water for several minutes (P305+P351+P338).

Is 4′-Hydroxy-3′-iodoacetophenone a controlled substance?

Based on the provided data, 4′-Hydroxy-3′-iodoacetophenone is not indicated as a controlled substance. However, end-users should always verify relevant local regulations.

How is this chemical shipped and exported?

Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, handling packaging and shipping according to international regulations for hazardous materials.

How can I request a quote or sample?

To request a quote or sample of 4′-Hydroxy-3′-iodoacetophenone, please contact our sales department through the website or via email, providing your requirements and shipping details.