4-Fluorophenyl chloroformate
4-Fluorophenyl chloroformate (CAS 38377-38-7) is a fluorinated organic compound with the linear formula ClCO<sub>2</sub>C<sub>6</sub>H<sub>4</sub>F and a molecular weight of 174.56 g/mol. This acid halide serves as a valuable building block in organic synthesis, particularly for introducing the 4-fluorophenoxycarbonyl group into molecules. It is a reactive intermediate used in the preparation of various chemical compounds, finding applications in research and development settings.
Organic Synthesis Reagent
4-Fluorophenyl chloroformate is utilised as a key reagent in organic synthesis for derivatisation reactions. It readily reacts with nucleophiles such as alcohols and amines to form carbonates and carbamates, respectively.
Pharmaceutical Intermediates
This compound acts as a building block in the synthesis of complex organic molecules, including potential pharmaceutical intermediates. The introduction of the fluorophenyl moiety can influence the pharmacokinetic properties of drug candidates.
Agrochemical Research
The reactivity of 4-Fluorophenyl chloroformate makes it a useful component in the exploratory synthesis of novel agrochemicals. Its incorporation can lead to compounds with specific biological activities.
Material Science
As a functionalised aromatic compound, it may be employed in research for developing new polymers or specialised materials where the fluorophenyl group imparts desired characteristics.
| Molecular weight | 174.56 |
|---|---|
| Linear formula | ClCO2C6H4F |
| Assay | 98% |
| Density | 1.329 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4933(lit.) |
| Storage temperature | 2-8°C |
Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H314Causes severe skin burns and eye damage
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 76 °C / 168.8 °F |
| Transport (UN / ADR) | UN 3277 6.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25-34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluorophenyl chloroformate used for?
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4-Fluorophenyl chloroformate is primarily used as a reagent in organic synthesis for introducing the 4-fluorophenoxycarbonyl group, serving as a building block for pharmaceuticals, agrochemicals, and research chemicals.
What is the CAS number and formula for 4-Fluorophenyl chloroformate?
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The CAS number is 38377-38-7 and the linear formula is ClCO<sub>2</sub>C<sub>6</sub>H<sub>4</sub>F.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Fluorophenyl chloroformate with an assay of 98%. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should 4-Fluorophenyl chloroformate be handled safely?
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Due to its hazardous nature (Danger, H301-H311-H314-H331), handle 4-Fluorophenyl chloroformate with extreme caution. Use full-face respirators, chemical-resistant gloves, and goggles. Work in a well-ventilated area or fume hood. Refer to the Safety Data Sheet for detailed handling procedures.
Is 4-Fluorophenyl chloroformate packed and shipped internationally by TSS?
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Yes, Tech Serve Solutions exports and supplies chemicals globally, adhering to all relevant shipping regulations for hazardous materials such as UN 3277.
How can I request a quote or sample for 4-Fluorophenyl chloroformate?
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To request a quote or sample, please contact our sales team via the website or by phone, providing your details and the product of interest.
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