4-Ethylphenylmagnesium bromide solution
4-Ethylphenylmagnesium bromide solution (CAS: 22873-28-5), with the linear formula C2H5C6H4MgBr and a molecular weight of 209.37, is a versatile Grignard reagent. Supplied as a 0.5 M solution in Tetrahydrofuran (THF), it is a valuable tool in organic synthesis for introducing the 4-ethylphenyl group. This organometallic compound is crucial for forming new carbon-carbon bonds in the preparation of complex organic molecules, pharmaceuticals, and advanced materials.
Carbon-Carbon Bond Formation
As a Grignard reagent, 4-ethylphenylmagnesium bromide is widely employed to create new carbon-carbon bonds through nucleophilic addition to carbonyl compounds, epoxides, and other electrophiles. This is fundamental in building complex organic frameworks.
Synthesis of Pharmaceutical Intermediates
This reagent serves as a key building block in the multi-step synthesis of various pharmaceutical intermediates. Its ability to selectively introduce the 4-ethylphenyl moiety is critical for developing active pharmaceutical ingredients (APIs).
Organometallic Chemistry Research
It is utilised in academic and industrial research laboratories for exploring novel synthetic pathways and developing new organometallic compounds. Its reactivity profile makes it a subject of study in reaction mechanism investigations.
Preparation of Specialty Chemicals
The compound is instrumental in the synthesis of fine chemicals and specialty organic materials where the incorporation of an ethylphenyl group is required for specific material properties or functionalities.
| Molecular weight | 209.37 |
|---|---|
| Linear formula | C2H5C6H4MgBr |
| Boiling point | 65 °C |
| Density | 0.950 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Ethylphenylmagnesium bromide solution used for?
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4-Ethylphenylmagnesium bromide solution is primarily used in organic synthesis for carbon-carbon bond formation, the synthesis of pharmaceutical intermediates, and the preparation of specialty chemicals. It acts as a nucleophilic source of the 4-ethylphenyl group.
What are the CAS number and formula for 4-Ethylphenylmagnesium bromide solution?
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The CAS number is 22873-28-5 and the linear formula is C2H5C6H4MgBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 0.5 M solution in THF. TSS does not represent this product as USP/BP/EP or any pharmacopoeia grade.
How should 4-Ethylphenylmagnesium bromide solution be handled and stored?
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This is a highly flammable liquid and vapour (H225) that can cause serious eye irritation (H319) and may cause respiratory irritation (H335). It is also suspected of causing cancer (H351) and may form explosive peroxides. Store in a cool, well-ventilated place away from heat and ignition sources, at 2-8°C, and handle under an inert atmosphere.
Is 4-Ethylphenylmagnesium bromide solution shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and can export 4-Ethylphenylmagnesium bromide solution worldwide.
How can I request a quote or sample for 4-Ethylphenylmagnesium bromide solution?
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To request a quote or sample, please contact the Tech Serve Solutions sales team via the website or provide your inquiry details through the contact form.
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