4-Cyano-4-phenylpiperidine hydrochloride
4-Cyano-4-phenylpiperidine hydrochloride (CAS: 51304-58-6; Formula: C12H14N2 · HCl) is a fine chemical with a molecular weight of 222.71 g/mol. This compound serves as a valuable building block in organic synthesis. It is primarily employed as a reactant for the preparation of various complex molecules, including pharmaceutical intermediates and research compounds with potential biological activities, such as CCR5 antagonists and neurotransmitter transporter inhibitors.
- IUPAC
- 4-Phenyl-4-piperidinecarbonitrile hydrochloride
- Synonyms
- 4-Phenyl-4-piperidinecarbonitrile hydrochloride
Synthesis of CCR5 Antagonists
This compound is a key reactant in the synthesis of CCR5 antagonists, which are derived at the N-terminal of the piperidine ring. These molecules are of interest for their potential therapeutic applications.
Development of Chemokine Receptor Ligands
It is used in the preparation of substituted piperidines that act as ligands for chemokine receptor 5, showing potential as inhibitors of HIV-1.
Preparation of Functionalised Heterocycles
The chemical is employed in synthetic routes to functionalised nitrogen heterocycles, achieved through radical decarboxylation methods involving beta- and gamma- amino acids.
Synthesis of Imaging Probes
It serves as a precursor for the development of benzovesamicol analogues designed as potential imaging probes for vesicular acetylcholine transporters.
Neurotransmitter Transporter Inhibitor Synthesis
This piperidine derivative is utilised in the synthesis of compounds that inhibit neurotransmitter transporters, exhibiting activity at dopamine receptor sites.
Selective Adrenoceptor Antagonist Development
The compound is a reactant in the synthesis of selective alpha1a adrenoceptor antagonists, which are compounds designed for specific pharmacological targets.
| Molecular weight | 222.71 |
|---|---|
| Empirical formula | C12H14N2 · HCl |
| Assay | 97% |
| Application | Reactant for synthesis of:• CCR5 antagonists derived at the N-terminal of the piperidine ring1• Substituted piperidines as lignads of chemokine receptor 5 and inhibitors of HIV-12• Functionalized nitrogen heterocycles by radical decarboxylation of β- and γ- amino acids3• Benzovesamicol analogs as potential imaging probes for vesicular acetylcholine transporters4• Neurotransmitter transporter inhibitors with activity at dopamine receptor sites5• α1a Adrenoceptor-selective antagonists6 |
| Melting point | 208-210 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Cyano-4-phenylpiperidine hydrochloride used for?
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4-Cyano-4-phenylpiperidine hydrochloride is used as a reactant in the synthesis of various complex organic molecules, including potential pharmaceutical intermediates like CCR5 antagonists, neurotransmitter transporter inhibitors, and selective alpha1a adrenoceptor antagonists.
What is the CAS number and chemical formula?
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The CAS number for 4-Cyano-4-phenylpiperidine hydrochloride is 51304-58-6, and its chemical formula is C12H14N2 · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Cyano-4-phenylpiperidine hydrochloride with an assay of 97%. This product is not represented as USP, BP, EP, or any other pharmacopoeia grade; it is supplied for research and chemical synthesis purposes.
How should 4-Cyano-4-phenylpiperidine hydrochloride be handled safely?
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This compound is classified as harmful if swallowed, in contact with skin, or if inhaled, and causes skin and serious eye irritation, and may cause respiratory irritation. Appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves, must be used. Ensure good ventilation and avoid breathing dust. Handle in accordance with the precautionary statements: P261, P280, P305 + P351 + P338.
Is this chemical a controlled substance?
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Based on the provided data, there is no indication that 4-Cyano-4-phenylpiperidine hydrochloride is a controlled substance.
How is this product packed and shipped?
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This chemical is carefully packed to ensure integrity during transit and is exported globally by Tech Serve Solutions, adhering to all relevant shipping regulations for fine chemicals.
How can I request a sample or quote?
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To request a sample or a quote for 4-Cyano-4-phenylpiperidine hydrochloride, please use the contact form on the Tech Serve Solutions website or email our sales department, providing your specific requirements.
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