4-Chlorouracil
4-Chlorouracil (CAS: 4270-27-3; Formula: C4H3ClN2O2; Molar Mass: 146.53 g/mol) is a halogenated pyrimidine base supplied by Tech Serve Solutions. This compound is valuable for investigating how halogenation impacts the stability of nucleic acid base pairs and their affinity for alkali metal ions. It serves as a reagent in chemical synthesis, particularly for creating substituted uracil derivatives.
- IUPAC
- 4-Chloro-2,6-dihydroxypyrimidine,6-Chloro-2,4-dihydroxypyrimidine,6-Chlorouracil
Nucleic Acid Research
4-Chlorouracil is employed in studies to understand the effects of halogenation on the stability and ion-binding properties of nucleic acid base pairs, contributing to fundamental biochemical research.
Organic Synthesis Intermediate
This compound acts as a precursor in the synthesis of novel nucleoside analogs and other heterocyclic compounds, enabling the development of new chemical entities.
Biochemical Studies
It is utilized as a research chemical to explore modifications in nucleobases and their subsequent impact on biological processes and molecular interactions.
| Molecular weight | 146.53 |
|---|---|
| Empirical formula | C4H3ClN2O2 |
| Assay | ≥99% |
| Application | Chlorouracil (4-Chlorouracil; 6-Chlorouracil) is a halogenated uracil that is useful in studies of the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity.Reaction of 6-chlorouracil with 4-(dimethylamino)pyridine, 4-methylpyridine, and pyridin-4-yl-morpholine yielded pyridinium-substituted uracils as chlorides which were converted into pyridinium uracilates by deprotonation. These heterocyclic mesomeric betaines are cross-conjugated and thus possess separate cationic (pyridinium) and anionic (uracilate) moieties. Calculations and X-ray single crystal analyses may be used to characterize these systems and to compare the salts with the betaines. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What are the primary uses of 4-Chlorouracil?
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4-Chlorouracil is primarily used in biochemical research to study the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity, and as an intermediate in organic synthesis for creating substituted uracil derivatives.
What is the CAS number and formula for 4-Chlorouracil?
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The CAS number for 4-Chlorouracil is 4270-27-3, and its chemical formula is C4H3ClN2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Chlorouracil with an assay of ≥99%. We do not represent this product as USP, BP, EP, or any pharmacopoeia grade.
How should 4-Chlorouracil be handled safely?
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Handle 4-Chlorouracil with appropriate personal protective equipment, including a dust mask (type N95 or equivalent), eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation. Refer to the safety data sheet for detailed handling instructions.
Is 4-Chlorouracil a controlled substance?
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The provided data does not indicate that 4-Chlorouracil is a controlled substance.
How is 4-Chlorouracil packed and shipped?
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4-Chlorouracil is carefully packed to ensure safe transit and is available for export globally by Tech Serve Solutions.
How can I request a quote or sample for 4-Chlorouracil?
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To request a quote or sample of 4-Chlorouracil, please contact our sales department through the TSS website or by phone.
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