4-Chloro-7-nitrobenzofurazan
4-Chloro-7-nitrobenzofurazan (CAS: 10199-89-0; Formula: C6H2ClN3O3; Molar Mass: 199.55 g/mol) is a specialised chemical reagent known for its fluorescent properties. It serves as a critical building block and derivatization agent in various analytical and synthetic applications, particularly in biochemical research and pharmaceutical analysis. TSS supplies this compound with a purity of 98% for research and development purposes.
- IUPAC
- 4-Chloro-7-nitro-1,2,3-benzoxadiazole,NBD-chloride
Fluorescent Labeling
Utilised as a fluorescent probe and derivatization agent, 4-Chloro-7-nitrobenzofurazan enables the spectrophotometric and spectrofluorometric determination of various pharmaceutical compounds. It is also employed in the synthesis of fluorescent phospholipid derivatives for biochemical studies.
Chemical Synthesis
This compound acts as a valuable building block in organic synthesis. Its structure, featuring a nitrobenzofurazan core with a reactive chlorine atom, allows for the creation of more complex molecules, including functionalized heterocycles for research applications.
Pharmaceutical Analysis
4-Chloro-7-nitrobenzofurazan is instrumental in the quantitative analysis of active pharmaceutical ingredients such as clemastine hydrogen fumarate, loratadine, losartan potassium, and ramipril within pharmaceutical formulations, aiding quality control processes.
| Molecular weight | 199.55 |
|---|---|
| Empirical formula | C6H2ClN3O3 |
| Assay | 98% |
| Solubility | chloroform: soluble50 mg/mL, clear to slightly hazy, faintly yellow to yellow |
| Application | 4-Chloro-7-nitrobenzofurazan (NBD-chloride) was used in the synthesis of fluorescent phospholipid-derivative, NBD-didecanoylphosphatidylethanolamine1 and functionalized hydroxynaphthofurazan2. It was used in spectrophotometric and spectrofluorometric determination of clemastine hydrogen fumarate, loratadine, losartan potassium and ramipril in pharmaceutical formulations3. |
| Suitability | suitable for fluorescence |
| Melting point | 97-99 °C(lit.) |
Hazard statements
- H301Toxic if swallowed
Precautionary statements
- P301IF SWALLOWED
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Fluorescence | λex 336 nm in methanolλex 420 nm; λem ~540 nm in ethanol (after derivatization with glycine) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Chloro-7-nitrobenzofurazan used for?
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4-Chloro-7-nitrobenzofurazan is used as a fluorescent probe, a derivatization agent for spectrophotometric and spectrofluorometric analysis of pharmaceuticals, and as a building block in chemical synthesis.
What is the CAS number and formula for 4-Chloro-7-nitrobenzofurazan?
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The CAS number is 10199-89-0 and the molecular formula is C6H2ClN3O3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Chloro-7-nitrobenzofurazan with an assay of 98%. It is supplied for research and development; TSS does not represent it as USP, BP, or EP grade.
How should 4-Chloro-7-nitrobenzofurazan be handled safely?
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4-Chloro-7-nitrobenzofurazan is classified as dangerous. Handling requires appropriate personal protective equipment including a dust mask (type N95 US), eyeshields, faceshields, and gloves, due to its toxic nature upon ingestion.
How is 4-Chloro-7-nitrobenzofurazan packed, shipped, or exported?
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This chemical is packed according to international shipping regulations for hazardous materials, including UN 2811 classification, and is exported globally by TSS.
How can I request a sample or quote for 4-Chloro-7-nitrobenzofurazan?
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To request a sample or a quotation, please contact the TSS sales team through our website or by phone, providing your specific requirements.
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