4-Chloro-2-methylthiopyrimidine
4-Chloro-2-methylthiopyrimidine (CAS: 49844-90-8) is a halogenated pyrimidine derivative with the molecular formula C5H5ClN2S and a molecular weight of 160.62 g/mol. This compound serves as a valuable building block in organic synthesis, particularly within medicinal chemistry. Its chemical structure allows for diverse reactions, making it instrumental in the development of novel pharmaceutical candidates and complex molecular architectures. It is supplied by Tech Serve Solutions for research and development purposes.
Marine Alkaloid Synthesis
4-Chloro-2-methylthiopyrimidine has been employed in the total synthesis of natural products, including the marine alkaloid variolin B. This application highlights its utility in constructing complex bioactive molecules.
Kinase Inhibitor Development
This compound acts as a key intermediate in the synthesis of 2,4-disubstituted pyrimidines, a novel class of potent KDR kinase inhibitors. Research in this area focuses on developing new therapeutic agents.
Medicinal Chemistry Building Block
Utilised as a versatile building block in medicinal chemistry, 4-Chloro-2-methylthiopyrimidine facilitates the creation of diverse molecular scaffolds for drug discovery programs. Its reactive sites allow for various derivatisations.
Synthesis of Pyrimidine Derivatives
It is used in the synthesis of 2-hydroxy-4-pyrimidinecarboxylic acid and other substituted pyrimidines. These derivatives are investigated for their potential biological activities.
| Molecular weight | 160.62 |
|---|---|
| Empirical formula | C5H5ClN2S |
| Assay | 98% |
| Boiling point | 139-140 °C/36 mmHg(lit.) |
| Density | 1.381 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.6(lit.) |
| Application | 4-Chloro-2-methylthiopyrimidine was used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid1. It was used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors2. It was used as building block in medicinal chemistry synthesis.3,4 |
| Melting point | −2 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 1760 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Chloro-2-methylthiopyrimidine used for?
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4-Chloro-2-methylthiopyrimidine is primarily used as a building block in organic synthesis, particularly in medicinal chemistry for the development of pharmaceutical intermediates and novel compounds, such as kinase inhibitors and in the synthesis of marine alkaloids.
What are the CAS number and formula for 4-Chloro-2-methylthiopyrimidine?
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The CAS number is 49844-90-8 and the empirical formula (Hill notation) is C5H5ClN2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Chloro-2-methylthiopyrimidine with a minimum assay of 98%. TSS does not represent this product as USP, BP, or EP grade.
How should 4-Chloro-2-methylthiopyrimidine be handled safely?
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This compound is classified as Danger, causing severe skin burns and eye damage (H314). Appropriate personal protective equipment, including face shields, gloves, goggles, and a suitable respirator, must be used. Handle in a well-ventilated area and avoid contact with skin and eyes.
Is 4-Chloro-2-methylthiopyrimidine available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 4-Chloro-2-methylthiopyrimidine.
How can I request a quote or sample?
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Please contact our sales team through the website or by phone to request a quote or a sample of 4-Chloro-2-methylthiopyrimidine.
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