4-Chloro-2-methylphenylmagnesium bromide solution
4-Chloro-2-methylphenylmagnesium bromide solution (CAS 480438-47-9) is an organometallic reagent with the linear formula ClC<sub>6</sub>H<sub>3</sub>(CH<sub>3</sub>)MgBr and a molecular weight of 229.78 g/mol. Supplied as a 0.5 M solution in THF, this Grignard reagent is a valuable tool in organic synthesis for forming new carbon-carbon bonds. It is primarily utilised in chemical synthesis as an intermediate for more complex molecules.
Carbon-Carbon Bond Formation
As a Grignard reagent, 4-Chloro-2-methylphenylmagnesium bromide is highly effective in nucleophilic addition reactions, enabling the formation of new carbon-carbon bonds with electrophiles such as aldehydes, ketones, and esters.
Synthesis of Arylated Compounds
This reagent facilitates the introduction of the 4-chloro-2-methylphenyl moiety into organic molecules, serving as a crucial building block in the synthesis of various complex arylated compounds.
Pharmaceutical Intermediate Synthesis
It can be employed in the multi-step synthesis pathways for creating advanced intermediates required in the development of novel pharmaceutical agents.
| Molecular weight | 229.78 |
|---|---|
| Linear formula | ClC6H3(CH3)MgBr |
| Boiling point | 65-67 °C |
| Density | 0.959 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-19-34-37-40 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Chloro-2-methylphenylmagnesium bromide solution used for?
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4-Chloro-2-methylphenylmagnesium bromide solution is used in organic synthesis, particularly for carbon-carbon bond formation and the synthesis of arylated compounds and pharmaceutical intermediates.
What is the CAS number and formula for this compound?
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The CAS number is 480438-47-9, and the linear formula is ClC<sub>6</sub>H<sub>3</sub>(CH<sub>3</sub>)MgBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Chloro-2-methylphenylmagnesium bromide solution at a concentration of 0.5 M in THF. We do not represent this product as USP, BP, or EP grade.
How should 4-Chloro-2-methylphenylmagnesium bromide solution be handled safely?
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This solution is flammable, corrosive, and may cause respiratory irritation. It reacts violently with water and may form explosive peroxides. Handle with extreme caution in a well-ventilated area, wearing appropriate personal protective equipment, and avoid contact with water and ignition sources. Store at 2-8°C.
Is 4-Chloro-2-methylphenylmagnesium bromide solution available for international export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and reagents, including 4-Chloro-2-methylphenylmagnesium bromide solution.
How can I request a sample or quote for 4-Chloro-2-methylphenylmagnesium bromide solution?
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Please contact our sales team directly via the website or phone to request a sample or a formal quotation for 4-Chloro-2-methylphenylmagnesium bromide solution.
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