4-Bromo-4′-fluorobiphenyl
4-Bromo-4′-fluorobiphenyl (CAS: 398-21-0, Formula: BrC₆H₄C₆H₄F, MW: 251.09) is a fluorinated aryl building block supplied by Tech Serve Solutions. This compound serves as a valuable intermediate in organic synthesis, particularly for the construction of complex molecules in materials science and pharmaceutical research. Its defined structure, featuring both bromine and fluorine substituents on a biphenyl core, allows for versatile derivatization and incorporation into larger chemical structures.

Organic Synthesis Intermediate
Utilised as a key building block in the synthesis of advanced organic molecules. The presence of both a bromine and a fluorine atom allows for selective functionalisation through various coupling reactions and nucleophilic aromatic substitution.
Materials Science
A precursor for the development of novel organic electronic materials, such as liquid crystals or organic light-emitting diodes (OLEDs). Its rigid biphenyl structure can contribute to desirable material properties.
Pharmaceutical Research
Employed in the synthesis of potential drug candidates and pharmaceutical intermediates. The fluorinated biphenyl motif is present in various biologically active compounds.
| Molecular weight | 251.09 |
|---|---|
| Linear formula | BrC6H4C6H4F |
| Assay | 97% |
| Melting point | 92.5-97.5 °C(lit.) |



Hazard statements
- H302Harmful if swallowed
- H318Causes serious eye damage
- H410Very toxic to aquatic life with long-lasting effects
Precautionary statements
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P501Dispose of contents and container per local regulations
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3152PSN1 9 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi,N |
| Risk statements (R) | 41-50/53 |
| Safety statements (S) | 26-39-60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Bromo-4′-fluorobiphenyl used for?
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4-Bromo-4′-fluorobiphenyl (CAS: 398-21-0) is primarily used as an intermediate in organic synthesis for creating complex molecules in materials science and pharmaceutical research.
What are the CAS number and formula for 4-Bromo-4′-fluorobiphenyl?
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The CAS number is 398-21-0 and the molecular formula is BrC₆H₄C₆H₄F.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Bromo-4′-fluorobiphenyl with an assay of 97%. We do not represent this product as USP, BP, EP, or other pharmacopoeial grades.
How should 4-Bromo-4′-fluorobiphenyl be handled safely?
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This compound is classified as Danger, with hazards including H302 (Harmful if swallowed), H318 (Causes serious eye damage), and H410 (Very toxic to aquatic life with long lasting effects). Handle with appropriate personal protective equipment: a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation and avoid release to the environment.
Is 4-Bromo-4′-fluorobiphenyl a controlled substance?
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The provided data does not indicate that 4-Bromo-4′-fluorobiphenyl is a controlled substance.
How is 4-Bromo-4′-fluorobiphenyl packed and exported?
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This chemical is shipped under UN 3152, Hazard Class 9, Packing Group II. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals.
How can I request a quote or sample for 4-Bromo-4′-fluorobiphenyl?
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Please contact our sales team via the website or your usual representative to request a quotation or a sample.
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