4-Bromo-3-(trifluoromethyl)aniline
4-Bromo-3-(trifluoromethyl)aniline (CAS 393-36-2) is an organic compound with the formula BrC6H3(CF3)NH2 and a molecular weight of 240.02 g/mol. This brominated and trifluoromethylated aniline derivative serves as a valuable building block in chemical synthesis. It is employed in the preparation of various organic compounds, including halogenated aromatics and biologically active molecules, underscoring its utility in research and development across different chemical sectors.
Synthesis of Halogenated Aromatics
4-Bromo-3-(trifluoromethyl)aniline is utilised in synthetic pathways to produce specialised di-halogenated benzene derivatives, such as 2,5-dibromo-(trifluoromethyl)benzene and 2-bromo-5-iodo-(trifluoromethyl)benzene.
Pharmaceutical Intermediate
This compound acts as a key intermediate in the synthesis of complex pharmaceutical agents. For instance, it has been used in the preparation of AUY954, an agonist for sphingosine-1-phosphate receptors.
Organic Building Block
Its structure, featuring both a bromine atom and a trifluoromethyl group on an aniline core, makes it a versatile building block for creating diverse organic molecules in research and development.
| Molecular weight | 240.02 |
|---|---|
| Linear formula | BrC6H3(CF3)NH2 |
| Assay | 98% |
| Boiling point | 81-84 °C/0.5 mmHg(lit.) |
| Application | 4-Bromo-3-(trifluoromethyl)aniline has been used in the preparation of:• 2,5-dibromo-(trifluoromethyl)benzene and 2-bromo-5-iodo-(trifluoromethyl)benzene1• AUY954, an aminocarboxylate analog of FTY720, a low nanomolar, monoselective agonist of the sphingosine-1-phosphate receptor2 |
| Melting point | 47-49 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Bromo-3-(trifluoromethyl)aniline used for?
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4-Bromo-3-(trifluoromethyl)aniline is used as a building block in organic synthesis, including the preparation of halogenated aromatics and pharmaceutical intermediates like AUY954.
What are the CAS number and chemical formula for 4-Bromo-3-(trifluoromethyl)aniline?
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The CAS number is 393-36-2 and the chemical formula is BrC6H3(CF3)NH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Bromo-3-(trifluoromethyl)aniline with a purity of 98%. We do not represent this product as USP, BP, or EP grade.
How should 4-Bromo-3-(trifluoromethyl)aniline be handled safely?
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Handling requires appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves. Avoid breathing dust, fumes, gas, mist, vapours, or spray. In case of contact, especially with eyes, rinse cautiously with water for several minutes and seek medical advice if irritation persists.
Is 4-Bromo-3-(trifluoromethyl)aniline a controlled substance?
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The provided data does not indicate that 4-Bromo-3-(trifluoromethyl)aniline is a controlled substance.
How is 4-Bromo-3-(trifluoromethyl)aniline packed and exported?
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Products are carefully packed according to international shipping regulations and are available for global export by Tech Serve Solutions.
How can I request a quote or sample for 4-Bromo-3-(trifluoromethyl)aniline?
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Please contact our sales team or use the online inquiry form to request a quotation or a sample of 4-Bromo-3-(trifluoromethyl)aniline.
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