4-Bromo-2-fluorophenyl isocyanate
4-Bromo-2-fluorophenyl isocyanate (CAS: 88112-75-8, BrC6H3(F)NCO) is a fluorinated aryl building block with a molecular weight of 216.01. This compound serves as a valuable intermediate in organic synthesis, particularly for the introduction of the 4-bromo-2-fluorophenylcarbamoyl moiety into various molecules. It is utilized in the development of novel chemical entities for research and development purposes, contributing to advancements in materials science and medicinal chemistry.
Organic Synthesis Intermediate
Utilised as a key building block for constructing complex organic molecules. Its isocyanate group readily reacts with nucleophiles like amines and alcohols, enabling the formation of urea and carbamate linkages.
Pharmaceutical Research
Serves as a precursor in the synthesis of potential drug candidates and biologically active compounds. The presence of bromine and fluorine atoms can influence pharmacokinetic and pharmacodynamic properties.
Materials Science
Involved in the development of functionalised polymers and materials. The unique electronic and steric properties imparted by the bromo and fluoro substituents can modify material characteristics.
| Molecular weight | 216.01 |
|---|---|
| Linear formula | BrC6H3(F)NCO |
| Assay | 97% |
| Boiling point | 56 °C/0.1 mmHg(lit.) |
| Density | 1.664 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.567(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 2206 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Bromo-2-fluorophenyl isocyanate used for?
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4-Bromo-2-fluorophenyl isocyanate is primarily used as an intermediate in organic synthesis, particularly in the pharmaceutical and materials science sectors for the development of novel chemical entities and functionalised materials.
What are the CAS number and chemical formula for 4-Bromo-2-fluorophenyl isocyanate?
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The CAS number is 88112-75-8, and the chemical formula is BrC6H3(F)NCO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Bromo-2-fluorophenyl isocyanate with a minimum assay of 97%. This product is suitable for research and chemical synthesis; TSS does not represent it as USP, BP, or EP grade.
How should 4-Bromo-2-fluorophenyl isocyanate be handled safely?
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This compound is harmful if swallowed, inhaled, or in contact with skin, and causes skin and eye irritation. It may also cause respiratory irritation. Handle with appropriate personal protective equipment, including gloves, eyeshields, and a suitable respirator, in a well-ventilated area.
Is 4-Bromo-2-fluorophenyl isocyanate available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 4-Bromo-2-fluorophenyl isocyanate, ensuring secure and compliant international shipping.
How can I request a quote or sample for 4-Bromo-2-fluorophenyl isocyanate?
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To request a quote or sample, please contact our sales team through the website or by phone, providing the product name and CAS number (88112-75-8).
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