4-Bromo-1-butene
4-Bromo-1-butene (CAS: 5162-44-7) is a halogenated hydrocarbon with the linear formula BrCH2CH2CH=CH2 and a molecular weight of 135.00 g/mol. This versatile organic building block, typically supplied with an assay of ≥98.0% (GC), finds utility in complex organic synthesis. It is employed as a reagent in the preparation of various intermediates and target molecules, including biologically active compounds and fine chemicals.
Organic Synthesis Reagent
4-Bromo-1-butene serves as a key building block in multi-step organic syntheses. It is utilised for introducing the butenyl moiety into various molecular frameworks, facilitating the construction of complex organic structures.
Preparation of Benzoic Acid Derivatives
This compound was employed in the synthesis of 4-(3-butenyloxy)benzoic acid, a derivative that may find use in further chemical research or material science applications.
Total Synthesis of Natural Products
4-Bromo-1-butene has been instrumental in the total synthesis of natural products, such as the marine toxin largazole and the biotoxin gymnodimine, highlighting its importance in advanced synthetic chemistry.
Synthesis of Dienehydrazides
The compound is also utilised in the preparation of dienehydrazides, a class of organic compounds with potential applications in various chemical research fields.
| Molecular weight | 135.00 |
|---|---|
| Linear formula | BrCH2CH2CH=CH2 |
| Assay | ≥98.0% (GC) |
| Boiling point | 98-100 °C(lit.) |
| Density | 1.33 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.462(lit.)n20/D 1.462 |
| Storage temperature | 2-8°C |
| Contains / stabiliser | silver wool as stabilizer |
| Application | • 4-Bromo-1-butene was used in the synthesis of 4-(3-butenyloxy)benzoic acid1. • It was also used in the total synthesis of largazole2. • It was used in double alkylation of lactams, followed by Grubbs ring-closing metathesis, to yield gymnodimine (biotoxin)3.• It was used in preparation of dienehydrazides4. |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
- P342
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 1 °C / 33.8 °F |
| Transport (UN / ADR) | UN 1993BF 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-36/37-42/43 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Bromo-1-butene used for?
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4-Bromo-1-butene is primarily used as a building block in organic synthesis for preparing complex molecules, including natural products like largazole and gymnodimine, and derivatives such as 4-(3-butenyloxy)benzoic acid and dienehydrazides.
What is the CAS number and formula for 4-Bromo-1-butene?
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The CAS number for 4-Bromo-1-butene is 5162-44-7, and its linear formula is BrCH2CH2CH=CH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Bromo-1-butene with an assay of ≥98.0% (GC). This product is typically considered technical or research grade and is not represented as USP, BP, EP, or other pharmacopoeial standards.
How should 4-Bromo-1-butene be handled safely?
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4-Bromo-1-butene is a highly flammable liquid and vapour, causes serious eye irritation, and may cause respiratory irritation. It is also a potential respiratory sensitiser. Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area. Store at 2-8°C.
How is 4-Bromo-1-butene packed, shipped, and exported?
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4-Bromo-1-butene is carefully packed in UN-approved containers suitable for hazardous materials. It is shipped and exported in compliance with all relevant international regulations for flammable liquids.
How can I request a sample or quote for 4-Bromo-1-butene?
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To request a sample or a quote for 4-Bromo-1-butene, please contact our sales team through the website or by calling our office. Please specify the quantity required and your delivery location.
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