4-Amino-3-nitrophenol
4-Amino-3-nitrophenol (CAS: 610-81-1), with the molecular formula H2NC6H3(NO2)OH and a molecular weight of 154.12 g/mol, is a valuable organic building block. This compound serves as a key intermediate in various chemical syntheses. Its applications include the development of Factor Xa inhibitors and the preparation of specialized phthalonitrile derivatives. It is also utilised in specific mass spectrometry techniques.
- IUPAC
- 4-Hydroxy-2-nitroaniline
- Synonyms
- 4-Hydroxy-2-nitroaniline
Synthesis of Benzimidazole-based Factor Xa Inhibitors
4-Amino-3-nitrophenol is employed as a precursor in the synthesis of complex organic molecules, specifically contributing to the creation of benzimidazole-based inhibitors targeting Factor Xa, a crucial enzyme in blood coagulation pathways.
Preparation of 4-(4-amino-3-nitrophenoxy)phthalonitrile
This compound serves as a starting material for the synthesis of 4-(4-amino-3-nitrophenoxy)phthalonitrile, a molecule relevant in the field of advanced materials or further organic synthesis.
Matrix for Mass Spectrometry
In analytical chemistry, 4-Amino-3-nitrophenol has been utilised as a matrix in visible matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), aiding in the analysis of various compounds.
| Molecular weight | 154.12 |
|---|---|
| Linear formula | H2NC6H3(NO2)OH |
| Assay | 98% |
| Application | 4-Amino-3-nitrophenol was used in the synthesis of benzimidazole based Factor Xa (trypsin-like serine protease) inhibitors1 and 4-(4-amino-3-nitrophenoxy)phthalonitrile2. It was also employed as matrix during visible matrix-assisted laser desorption/ionization mass spectrometry3. |
| Melting point | 150-154 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Amino-3-nitrophenol used for?
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4-Amino-3-nitrophenol is used in chemical synthesis, including the preparation of Factor Xa inhibitors and phthalonitrile derivatives, and as a matrix in mass spectrometry.
What is the CAS number and formula for 4-Amino-3-nitrophenol?
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The CAS number for 4-Amino-3-nitrophenol is 610-81-1 and its linear formula is H2NC6H3(NO2)OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Amino-3-nitrophenol with a minimum purity of 98%. We do not represent this product as USP, BP, or EP grade.
What are the safety precautions for handling 4-Amino-3-nitrophenol?
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Handle 4-Amino-3-nitrophenol with care. It is classified as causing skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Use a dust mask (N95), eyeshields, and gloves. Ensure adequate ventilation.
Is 4-Amino-3-nitrophenol exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 4-Amino-3-nitrophenol.
How can I request a quote or sample of 4-Amino-3-nitrophenol?
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Please contact our sales department via the website or by phone to request a quotation or to arrange for a sample of 4-Amino-3-nitrophenol.
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