4-Acetylphenylboronic acid
4-Acetylphenylboronic acid (CAS: 149104-90-5) is an organoboron compound with the chemical formula CH3COC6H4B(OH)2 and a molecular weight of 163.97 g/mol. It serves as a versatile building block in organic synthesis, particularly noted for its involvement in various palladium-catalyzed cross-coupling reactions and other transformations. This compound is a key intermediate for the synthesis of complex organic molecules, finding utility across research and development sectors.
Suzuki-Miyaura Cross-Coupling Reactions
4-Acetylphenylboronic acid is a valuable substrate in palladium-catalyzed Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds with aryl or vinyl halides and pseudohalides.
Palladium-Catalyzed Decarboxylative Coupling
This reagent participates in palladium-catalyzed decarboxylative coupling reactions, offering a synthetic route for the construction of diverse organic scaffolds.
Copper-Catalyzed Hydroxylation
It can be employed in copper-catalyzed hydroxylation reactions, introducing hydroxyl groups into organic structures.
Synthesis of Complex Molecules
Utilised in cross-coupling with α-bromocarbonyl compounds and other 1,5-substitution reactions, it facilitates the synthesis of intricate molecular architectures relevant to medicinal chemistry and materials science.
| Molecular weight | 163.97 |
|---|---|
| Linear formula | CH3COC6H4B(OH)2 |
| Application | Reactant involved in:• Palladium-catalyzed decarboxylative coupling1• Copper-catalyzed hydroxylation2• Palladium-catalyzed Suzuki-Miyaura cross-coupling3• Cross-coupling with α-bromocarbonyl compounds4• Oxidation catalyzed by Baeyer-Villiger monooxygenases5• 1,5-substitution reactions6 |
| Melting point | 240-244 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Acetylphenylboronic acid used for?
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4-Acetylphenylboronic acid is primarily used as a reactant and building block in organic synthesis. Its applications include palladium-catalyzed decarboxylative coupling, copper-catalyzed hydroxylation, Suzuki-Miyaura cross-coupling, and cross-coupling with α-bromocarbonyl compounds.
What are the CAS number and chemical formula for 4-Acetylphenylboronic acid?
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The CAS number for 4-Acetylphenylboronic acid is 149104-90-5, and its chemical formula is CH3COC6H4B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Acetylphenylboronic acid typically as a research or technical grade chemical. We do not represent this product as USP, BP, or EP grade. Please refer to the product's Certificate of Analysis for specific purity details.
How should 4-Acetylphenylboronic acid be handled safely?
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4-Acetylphenylboronic acid is classified with Warning. It is recommended to avoid breathing dust, and to use it with adequate ventilation. Always wear eyeshields, gloves, and a dust mask type N95 (US) when handling. Refer to the Safety Data Sheet for comprehensive handling information.
Can Tech Serve Solutions export 4-Acetylphenylboronic acid internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and we can arrange for the export of 4-Acetylphenylboronic acid to various international destinations. Please contact us for specific shipping inquiries.
How can I request a quote or sample for 4-Acetylphenylboronic acid?
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To request a quote or a sample of 4-Acetylphenylboronic acid, please visit our website or contact our sales department directly. Provide the product name and CAS number (149104-90-5) for prompt service.
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