3-Thiophenecarboxaldehyde
3-Thiophenecarboxaldehyde (CAS: 498-62-4; C5H4OS; MW: 112.15) is a key organic building block and heterocyclic compound. This aldehyde derivative of thiophene is recognised for its utility in synthetic organic chemistry. It serves as a valuable intermediate in the development of various chemical entities, particularly within pharmaceutical research and materials science. Available at 98% purity, it is suitable for demanding research and development applications.
Synthesis of Thiophene Derivatives
3-Thiophenecarboxaldehyde is employed in the synthesis of diverse thiophene-containing compounds, such as 4-substituted 2-thiophenesulfonamides, acting as a crucial starting material for complex molecular architectures.
Pharmaceutical Intermediate
This aldehyde is utilised in the creation of acetal and ketal derivatives of biologically active molecules, contributing to the development pipeline for new therapeutic agents.
Organic Synthesis Reagent
It participates in reactions to form novel compounds like 1,2-di-3-thienyl-2-hydroxyethanone (3,3′-thenoin), a symmetric analogue of benzoin, showcasing its versatility in chemical transformations.
| Molecular weight | 112.15 |
|---|---|
| Empirical formula | C5H4OS |
| Assay | 98% |
| Boiling point | 194-196 °C(lit.)86-87 °C/20 mmHg(lit.) |
| Density | 1.28 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.583(lit.) |
| Vapour pressure | 0.31 mmHg (20 °C) |
| Autoignition temp | >392 °F |
| Storage temperature | 2-8°C |
| Application | 3-Thiophenecarboxaldehyde has been used in the synthesis of:• series of 4-substituted 2-thiophenesulfonamides1• acetal and ketal derivatives of 4′-demethylepipodophyllotoxin-β-D-glucoside and epipodophyllotoxin-β-D-glucoside2• 1,2-di-3-thienyl-2-hydroxyethanone (3,3′-thenoin), 3-thienyl symmetric analog of benzoin3 |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 75 °C / 167 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Thiophenecarboxaldehyde used for?
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3-Thiophenecarboxaldehyde is primarily used as a building block in organic synthesis for creating thiophene derivatives, pharmaceutical intermediates, and other complex organic molecules.
What is the CAS number and chemical formula for 3-Thiophenecarboxaldehyde?
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The CAS number is 498-62-4 and the chemical formula is C5H4OS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Thiophenecarboxaldehyde with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 3-Thiophenecarboxaldehyde be handled safely?
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Warning: Harmful if swallowed (H302). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Store at 2-8°C. Refer to the Safety Data Sheet for detailed handling instructions.
Is 3-Thiophenecarboxaldehyde available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 3-Thiophenecarboxaldehyde.
How can I request a quote or sample?
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Please contact our sales team through the website to request a quote or sample of 3-Thiophenecarboxaldehyde.
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