3-Nitrobenzoyl chloride
3-Nitrobenzoyl chloride (CAS: 121-90-4) is an organic compound with the linear formula O₂NC₆H₄COCl and a molecular weight of 185.56 g/mol. This acid halide functions as a key building block in organic synthesis. It is primarily utilised in the preparation of various derivatives, including amides and esters, finding application in the development of specialised chemical compounds and pharmaceutical intermediates.
Synthesis of Amides
3-Nitrobenzoyl chloride serves as a crucial reagent for the acylation of amines, leading to the formation of amide linkages. For instance, it has been employed in the synthesis of 3-aminobenzamide, a derivative with potential applications in further chemical transformations.
Intermediate for Complex Molecules
This compound is utilised as a building block in the multi-step synthesis of more complex organic molecules. Its reactive acyl chloride group allows for facile introduction of the 3-nitrobenzoyl moiety into diverse molecular structures.
Research and Development
In research settings, 3-Nitrobenzoyl chloride is employed in the exploratory synthesis of novel chemical entities. It has been documented in the synthesis of potential carbocyclic minor groove binders, highlighting its utility in medicinal chemistry research.
| Molecular weight | 185.56 |
|---|---|
| Linear formula | O2NC6H4COCl |
| Assay | 98% |
| Boiling point | 275-278 °C(lit.) |
| Application | 3-Nitrobenzoyl chloride was used in the synthesis of 3-aminobenzamide1. It was also used to synthesize potential carbocyclic minor groove binders2. |
| Melting point | 31-34 °C(lit.) |
Hazard statements
- H311Toxic in contact with skin
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 110 °C / 230 °F |
| Transport (UN / ADR) | UN 2923 8/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 5-21-34-37 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Risk of explosion if heated under confinement. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Nitrobenzoyl chloride used for?
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3-Nitrobenzoyl chloride is used as a building block in organic synthesis, primarily for the preparation of amides and other derivatives. It has been used in the synthesis of compounds like 3-aminobenzamide and in the development of potential carbocyclic minor groove binders.
What is the CAS number and formula for 3-Nitrobenzoyl chloride?
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The CAS number for 3-Nitrobenzoyl chloride is 121-90-4 and its linear formula is O₂NC₆H₄COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Nitrobenzoyl chloride with a minimum assay of 98%. This product is intended for laboratory and industrial use; TSS does not represent it as USP, BP, EP or other pharmacopoeia grades.
What are the main hazards associated with 3-Nitrobenzoyl chloride?
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3-Nitrobenzoyl chloride is classified as corrosive and toxic. It causes severe skin burns and eye damage (H314) and is toxic in contact with skin (H311). There is also a risk of explosion if heated under confinement. Appropriate personal protective equipment, including eyeshields, face shields, and chemical-resistant gloves, must be worn.
How is 3-Nitrobenzoyl chloride packed and shipped?
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3-Nitrobenzoyl chloride is shipped as a hazardous material according to UN 2923 regulations. Packaging is designed to ensure safe transport and handling, complying with international shipping standards for corrosive and toxic substances.
How can I request a quote or sample for 3-Nitrobenzoyl chloride?
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To request a quote or sample of 3-Nitrobenzoyl chloride, please contact our sales department through the website or by phone. Please specify the quantity required and your shipping destination.
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