3-Methyl-2-thienylzinc bromide solution
3-Methyl-2-thienylzinc bromide solution (CAS 312693-45-1) is an organozinc halide with a molecular weight of 242.45 g/mol. It is supplied as a 0.5 M solution in THF. This reagent is primarily employed in organic synthesis, particularly for the introduction of the 3-methyl-2-thienyl moiety in cross-coupling reactions and other transformations involving organometallic intermediates. Its reactivity makes it valuable in the construction of complex molecules.
Organometallic Cross-Coupling Reactions
3-Methyl-2-thienylzinc bromide solution serves as a nucleophilic coupling partner in various transition metal-catalyzed cross-coupling reactions, such as Negishi coupling. It facilitates the formation of carbon-carbon bonds by transferring the 3-methyl-2-thienyl group to electrophilic substrates.
Heterocyclic Synthesis
This organozinc reagent is utilized in the synthesis of complex heterocyclic compounds containing the thiophene ring system. It enables the regioselective functionalization of thiophene derivatives, which are important scaffolds in medicinal chemistry and materials science.
Synthesis of Pharmaceutical Intermediates
The reagent can be employed in the multi-step synthesis of advanced intermediates for active pharmaceutical ingredients (APIs). Its controlled reactivity allows for precise incorporation of the thienyl fragment into drug candidate molecules.
| Molecular weight | 242.45 |
|---|---|
| Empirical formula | C5H5BrSZn |
| Boiling point | 65 °C |
| Density | 0.978 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H261In contact with water releases flammable gas
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P231Handle under inert gas
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
- P422
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-14-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Methyl-2-thienylzinc bromide solution used for?
+
3-Methyl-2-thienylzinc bromide solution is used in organic synthesis, particularly for introducing the 3-methyl-2-thienyl group in cross-coupling reactions and for constructing complex heterocyclic molecules.
What is the CAS number and formula for 3-Methyl-2-thienylzinc bromide solution?
+
The CAS number is 312693-45-1 and the empirical formula is C5H5BrSZn.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 3-Methyl-2-thienylzinc bromide solution at a concentration of 0.5 M in THF. We do not represent this product as USP, BP, or EP grade.
How should 3-Methyl-2-thienylzinc bromide solution be handled safely?
+
This reagent is flammable and reacts violently with water. It may form explosive peroxides. Handle with extreme care under an inert atmosphere, away from ignition sources and water. Consult the Safety Data Sheet (SDS) for full details.
How is 3-Methyl-2-thienylzinc bromide solution packed and shipped?
+
3-Methyl-2-thienylzinc bromide solution is packed according to UN 2924, Class 8(3), Packing Group II regulations for shipping and export.
How can I request a quote or sample?
+
To request a quote or sample, please contact our sales department through the website or by phone, providing the product name and CAS number.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis