3-Fluorobenzenesulfonyl chloride
3-Fluorobenzenesulfonyl chloride (CAS: 701-27-9, FC6H4SO2Cl) is a fluorinated aromatic compound with a molecular weight of 194.61 g/mol. This organosulfur compound functions as a valuable building block in organic synthesis, particularly for introducing the 3-fluorobenzenesulfonyl moiety into various molecular structures. It is commonly employed in the development of novel organic compounds and pharmaceutical intermediates due to the unique properties conferred by the fluorine atom and the sulfonyl chloride group.

Organic Synthesis Intermediate
3-Fluorobenzenesulfonyl chloride serves as a key intermediate in the synthesis of complex organic molecules. Its reactive sulfonyl chloride group readily participates in nucleophilic substitution reactions, enabling the formation of sulfonamides, sulfonates, and other sulfur-containing derivatives.
Pharmaceutical Research
This compound is utilised in the research and development of new pharmaceutical agents. The incorporation of fluorine can modulate a drug candidate's metabolic stability, lipophilicity, and binding affinity, making fluorinated building blocks like this one highly sought after in medicinal chemistry.
Agrochemical Development
It can be employed in the synthesis of novel agrochemicals, where the fluorinated phenyl ring and sulfonyl group may contribute to the biological activity of potential pesticides or herbicides.
Material Science Applications
The unique electronic properties of fluorinated aromatic compounds may lead to applications in the development of advanced materials, such as specialty polymers or electronic components.
| Molecular weight | 194.61 |
|---|---|
| Linear formula | FC6H4SO2Cl |
| Assay | 97% |
| Boiling point | 231-232 °C(lit.) |
| Density | 1.463 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.529(lit.) |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Fluorobenzenesulfonyl chloride used for?
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3-Fluorobenzenesulfonyl chloride is primarily used as a building block in organic synthesis, particularly in the development of pharmaceutical intermediates and novel organic compounds. Its reactive sulfonyl chloride group allows for the introduction of the 3-fluorobenzenesulfonyl moiety into target molecules.
What is the CAS number and chemical formula for 3-Fluorobenzenesulfonyl chloride?
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The CAS number for 3-Fluorobenzenesulfonyl chloride is 701-27-9, and its chemical formula is FC6H4SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Fluorobenzenesulfonyl chloride with an assay of 97%. We do not represent this product as USP, BP, or EP grade; it is suitable for research and general chemical synthesis purposes.
How should 3-Fluorobenzenesulfonyl chloride be handled safely?
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3-Fluorobenzenesulfonyl chloride is a hazardous substance labelled with GHS05 and the signal word 'Danger'. It causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including full-face respirators, gloves, and eye protection, must be used. Handle only in a well-ventilated area or under a fume hood.
Is 3-Fluorobenzenesulfonyl chloride available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 3-Fluorobenzenesulfonyl chloride, to customers worldwide.
How can I request a quote or sample?
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To request a quote or a sample of 3-Fluorobenzenesulfonyl chloride, please contact our sales team through the provided contact channels on our website.
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