3-Ethoxymethacrolein
3-Ethoxymethacrolein (CAS: 42588-57-8) is an organic compound with the formula C2H5OCH=C(CH3)CHO and a molar mass of 114.14 g/mol. This ethoxy-substituted unsaturated aldehyde serves as a valuable building block in organic synthesis. It is primarily utilised in the creation of complex heterocyclic compounds and substituted quinolines, finding applications in pharmaceutical research and fine chemical manufacturing.
- IUPAC
- 3-Ethoxy-2-methylpropenal
Synthesis of Dideaza-Tetrahydrofolic Acid Analogues
3-Ethoxymethacrolein has been employed in the synthetic pathways leading to 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF), a compound of interest in medicinal chemistry.
Preparation of Quinolines
This chemical intermediate is used in modified Friedländer syntheses, a versatile method for constructing quinoline ring systems, which are prevalent in many pharmaceuticals and natural products.
Intermediate for Complex Organic Molecules
Its reactive aldehyde and enol ether functionalities make 3-Ethoxymethacrolein a useful synthon for building more complex organic structures, as demonstrated in its use for creating specific cyclohexyloxy derivatives.
| Molecular weight | 114.14 |
|---|---|
| Linear formula | C2H5OCH=C(CH3)CHO |
| Assay | 96% |
| Boiling point | 78-81 °C/14 mmHg(lit.) |
| Density | 0.96 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4792(lit.) |
| Storage temperature | 2-8°C |
| Application | 3-Ethoxymethacrolein was used in the synthesis of:• 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF)1• quinolines via modified Friedlander synthesis2• 3-[2-isopropyl-5-methylcyclohexyloxy-(1R, 2S, 5R)]-2-methyl-2E-propenal3 |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 35 °C / 95 °F |
| Transport (UN / ADR) | UN 3271 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Ethoxymethacrolein used for?
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3-Ethoxymethacrolein is used as a building block in organic synthesis, notably in the preparation of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid analogues and quinolines via modified Friedländer synthesis.
What is the CAS number and molecular formula for 3-Ethoxymethacrolein?
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The CAS number for 3-Ethoxymethacrolein is 42588-57-8, and its molecular formula is C2H5OCH=C(CH3)CHO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Ethoxymethacrolein with a minimum assay of 96%. We do not represent this product as USP, BP, or EP grade.
How should 3-Ethoxymethacrolein be handled and stored?
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3-Ethoxymethacrolein is a flammable liquid and vapour (H226), and is harmful if swallowed, in contact with skin, or if inhaled (H302 + H312 + H332). It should be stored at 2-8°C and handled with appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection.
Is 3-Ethoxymethacrolein a controlled substance?
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Based on the provided data, 3-Ethoxymethacrolein is not listed as a controlled substance.
How is 3-Ethoxymethacrolein shipped and exported?
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3-Ethoxymethacrolein is classified under UN 3271, Class 3, Packing Group III, indicating it is shipped as a flammable liquid. Tech Serve Solutions, as a specialist global supplier, exports chemicals adhering to all relevant international shipping regulations.
How can I request a sample or quote for 3-Ethoxymethacrolein?
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To request a sample or quote for 3-Ethoxymethacrolein, please contact the Tech Serve Solutions sales team through our website or by phone, referencing the product CAS number 42588-57-8.
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