3,5-Bis(trifluoromethyl)phenylboronic acid

CAS 73852-19-4(CF3)2C6H3B(OH)2Chemical Synthesis

3,5-Bis(trifluoromethyl)phenylboronic acid (CAS 73852-19-4) is a valuable organoboron compound with the linear formula (CF3)2C6H3B(OH)2 and a molecular weight of 257.93 g/mol. As a key intermediate in organic synthesis, it participates in various coupling reactions and is essential for constructing complex molecular architectures. Its applications span the development of novel pharmaceuticals, advanced materials, and complex organic molecules.

IUPAC: 3,5-Di(trifluoromethyl)benzeneboronic acid
Synonyms: (CF3)2C6H3B(OH)23,5-Di(trifluoromethyl)benzeneboronic acid

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3,5-Bis(trifluoromethyl)phenylboronic acid ((CF3)2C6H3B(OH)2) — chemical structure, CAS 73852-19-4; Chemistry, fine chemical supplied by Tech Serve Solutions

Aryl Boronic AcidsBoronic AcidsChemical Synthesis

01 /Applications

Synthesis of Methylene-arylbutenones

This boronic acid serves as a reactant in the synthesis of methylene-arylbutenones through the carbonylative arylation of allenols, a crucial transformation in organic synthesis.

Construction of 4-Aminoquinoline Analogues

It is employed in Ullman, Suzuki, and Negishi coupling reactions to generate 4-aminoquinoline analogues, which are important structural motifs in medicinal chemistry.

Preparation of Amino Acid Derivatives

The compound is utilized in the synthesis of primary amino acid derivatives possessing anticonvulsant activity, contributing to the development of potential therapeutic agents.

Formation of Alkyl Arylcarbamates

It participates in copper-catalyzed coupling reactions with potassium cyanate, leading to the formation of alkyl arylcarbamates.

Asymmetric Conjugate Addition Reactions

3,5-Bis(trifluoromethyl)phenylboronic acid is instrumental in the asymmetric conjugate addition to form aryl-substituted succinimides and cyclic ketones.

02 /Properties

Molecular weight	257.93
Linear formula	(CF3)2C6H3B(OH)2
Application	Reactant involved in the synthesis of:• Methylene-arylbutenones via carbonylative arylation of allenols1• 4-aminoquinoline analogs via Ullman / Suzuki / Negishi coupling2• Primary amino acid derivatives with anticonvulsant activity3• Alkyl arylcarbamates via Cu-catalyzed coupling with potassium cyanate4• Aryl-substituted succinimides and cyclic ketones by asymmetric conjugate addition5• Axially chiral dicarboxylic acids for asymmetric Mannich-type reactions6
Melting point	217-220 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

73852-19-4

MDL number

MFCD00051850

PubChem substance

24870695

Beilstein registry

7379990

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 3,5-Bis(trifluoromethyl)phenylboronic acid used for?

3,5-Bis(trifluoromethyl)phenylboronic acid is primarily used as a reactant in organic synthesis for creating methylene-arylbutenones, 4-aminoquinoline analogues, primary amino acid derivatives with anticonvulsant activity, alkyl arylcarbamates, aryl-substituted succinimides, cyclic ketones, and axially chiral dicarboxylic acids.

What is the CAS number and molecular formula for 3,5-Bis(trifluoromethyl)phenylboronic acid?

The CAS number is 73852-19-4, and the linear molecular formula is (CF3)2C6H3B(OH)2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this chemical as a research or technical grade. We do not represent it as USP, BP, EP, or pharmacopoeia grade.

What are the safety considerations for handling this chemical?

Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. It is classified under WGK 3 in Germany, indicating a high hazard level.

How is this chemical packed and shipped?

This chemical is carefully packed according to industry standards to ensure safe transit and is available for global export. Please contact us for specific shipping details.