3-Chloro-4-methoxyphenyl isocyanate
3-Chloro-4-methoxyphenyl isocyanate (CAS: 28395-76-8), with the molecular formula ClC6H3(OCH3)NCO and a molecular weight of 183.59 g/mol, is a versatile organic building block. This compound is primarily utilised in chemical synthesis as an intermediate for the production of more complex molecules. Its reactive isocyanate group makes it valuable for introducing specific functionalities in organic chemistry research and development.
Intermediate in Organic Synthesis
3-Chloro-4-methoxyphenyl isocyanate serves as a key intermediate in the synthesis of various organic compounds. Its isocyanate functionality readily reacts with nucleophiles, enabling the formation of ureas, carbamates, and amides, which are important structural motifs in pharmaceuticals and agrochemicals.
Reagent for Functionalisation
This compound can be employed as a reagent to introduce the 3-chloro-4-methoxyphenyl moiety into target molecules. This is particularly useful in medicinal chemistry for structure-activity relationship studies and the development of novel drug candidates.
Building Block for Heterocyclic Chemistry
The isocyanate group can participate in cyclisation reactions, making 3-Chloro-4-methoxyphenyl isocyanate a valuable building block for constructing heterocyclic compounds, which are prevalent in many biologically active molecules.
| Molecular weight | 183.59 |
|---|---|
| Linear formula | ClC6H3(OCH3)NCO |
| Assay | 97% |
| Melting point | 30-33 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3335 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 22-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Chloro-4-methoxyphenyl isocyanate used for?
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3-Chloro-4-methoxyphenyl isocyanate is primarily used as a building block and intermediate in organic synthesis for creating more complex molecules, particularly in the development of pharmaceuticals and agrochemicals.
What is the CAS number and chemical formula for 3-Chloro-4-methoxyphenyl isocyanate?
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The CAS number is 28395-76-8 and the chemical formula is ClC6H3(OCH3)NCO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Chloro-4-methoxyphenyl isocyanate with an assay of 97%. This is suitable for research and general chemical synthesis purposes. TSS does not represent this product as USP, BP, or EP grade.
How should 3-Chloro-4-methoxyphenyl isocyanate be handled safely?
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Handle with appropriate personal protective equipment, including a dust mask (N95 recommended), eyeshields, and gloves. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash skin thoroughly after handling. It is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and eye irritation.
How is 3-Chloro-4-methoxyphenyl isocyanate packed and shipped?
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3-Chloro-4-methoxyphenyl isocyanate is typically packed in suitable containers for safe transport. As per UN 3335, it is shipped as a miscellaneous dangerous good. TSS exports globally, adhering to all relevant shipping regulations.
How can I request a sample or quote for 3-Chloro-4-methoxyphenyl isocyanate?
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To request a sample or a quote for 3-Chloro-4-methoxyphenyl isocyanate, please use the contact form on our website or email our sales department, providing your details and requirements.
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