3-Bromopropionitrile
3-Bromopropionitrile (CAS: 2417-90-5), with the linear formula BrCH₂CH₂CN and a molecular weight of 133.97 g/mol, is a valuable organic building block. It functions as a key intermediate in chemical synthesis, particularly in reactions involving nitriles and nitrogen compounds. This compound is primarily used in research and industrial applications requiring precise chemical manipulation, such as initiating radical polymerizations and facilitating coupling reactions.
Initiator in Polymerisation
3-Bromopropionitrile serves as an initiator in atom transfer radical polymerisation (ATRP) processes, notably for the polymerisation of acrylonitrile. This application is crucial for synthesising specific polymer architectures and materials.
Coupling Reactions
It is employed in coupling reactions involving aromatic and heteroaromatic phenols. These reactions often utilise alkyl, acyl, or benzoyl halides in the presence of cesium fluoride-Celite in acetonitrile, enabling the formation of complex organic molecules.
Organic Synthesis Intermediate
As a functionalised nitrile, 3-Bromopropionitrile acts as a versatile intermediate in the synthesis of more complex organic compounds. Its reactivity allows for diverse transformations in multi-step synthetic routes.
| Molecular weight | 133.97 |
|---|---|
| Linear formula | BrCH2CH2CN |
| Assay | 99% |
| Boiling point | 76-78 °C/10 mmHg(lit.) |
| Density | 1.615 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.481(lit.) |
| Application | 3-Bromopropionitrile was used as the initiator in the atom transfer radical polymerization of acrylonitrile1. 3-Bromopropionitrile was used in coupling reactions of a number of aromatic and heteroaromatic phenols with alkyl, acyl or benzoyl halides in acetonitrile with cesium fluoride-Celite2. |
Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H331Toxic if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 97 °C / 206.6 °F |
| Transport (UN / ADR) | UN 3276 6.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25-36/37/38 |
| Safety statements (S) | 26-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Bromopropionitrile used for?
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3-Bromopropionitrile is used as an initiator in atom transfer radical polymerisation, particularly for acrylonitrile, and in coupling reactions of phenols with various halides. It is also a general intermediate in organic synthesis.
What is the CAS number and chemical formula for 3-Bromopropionitrile?
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The CAS number for 3-Bromopropionitrile is 2417-90-5, and its linear formula is BrCH₂CH₂CN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Bromopropionitrile with a purity of 99%. We do not represent this product as meeting any pharmacopoeia standards such as USP, BP, or EP.
How should 3-Bromopropionitrile be handled safely?
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3-Bromopropionitrile is a Danger substance (GHS06) and is toxic if swallowed, in contact with skin, or if inhaled (H301, H311, H331). It also causes skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate PPE, including eyeshields, faceshields, gloves, and respiratory protection (e.g., ABEK filter or multi-purpose combination cartridge), is essential. Handle only in well-ventilated areas and seek immediate medical attention in case of exposure.
Is 3-Bromopropionitrile typically exported by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 3-Bromopropionitrile.
How can I request a quote or sample for 3-Bromopropionitrile?
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To request a quote or sample, please contact our sales team through the website or by phone, providing the product name and CAS number (2417-90-5).
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