3-Bromo-2-fluorophenylboronic acid MIDA ester
3-Bromo-2-fluorophenylboronic acid MIDA ester (CAS: 1257647-82-7) is a halogenated aryl MIDA boronate, a valuable building block in organic synthesis. With a molecular weight of 329.91 g/mol, it is primarily utilised in Suzuki-Miyaura cross-coupling reactions. Its MIDA ester functionality offers enhanced stability and handling compared to free boronic acids, making it a preferred reagent for constructing complex organic molecules in pharmaceutical research and materials science.
Suzuki-Miyaura Cross-Coupling Reactions
This compound serves as a key coupling partner in palladium-catalysed Suzuki-Miyaura reactions. The MIDA ester moiety provides stability, allowing for controlled reactivity and efficient formation of new carbon-carbon bonds.
Synthesis of Biaryl Compounds
It is instrumental in synthesising substituted biaryl systems, which are prevalent structural motifs in many pharmaceuticals and advanced materials. The bromo and fluoro substituents offer further avenues for functionalisation.
Building Block for Complex Molecules
As a versatile intermediate, it enables the introduction of the 3-bromo-2-fluorophenyl group into more intricate molecular architectures, facilitating drug discovery and the development of novel organic compounds.
| Molecular weight | 329.91 |
|---|---|
| Empirical formula | C11H10BBrFNO4 |
| Assay | 97% |
| Application | Suzuki Cross-Coupling with MIDA Boronates |
| Melting point | 243-247 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Bromo-2-fluorophenylboronic acid MIDA ester used for?
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This compound is predominantly used as a building block in Suzuki-Miyaura cross-coupling reactions for the synthesis of complex organic molecules, particularly biaryl compounds, in pharmaceutical research and materials science.
What is the CAS number and formula for 3-Bromo-2-fluorophenylboronic acid MIDA ester?
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The CAS number is 1257647-82-7. The empirical formula (Hill notation) is C11H10BBrFNO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Bromo-2-fluorophenylboronic acid MIDA ester with a minimum assay of 97%. This product is intended for research and laboratory use and is not represented as USP, BP, EP, or pharmaceutical grade.
What are the safety and handling recommendations for this chemical?
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This compound is classified as a Warning. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Ensure adequate ventilation.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions ensures secure and compliant packaging for all chemicals, adhering to international shipping regulations for safe export worldwide. Specific packaging details are confirmed upon order.
How can I request a sample or a quote for 3-Bromo-2-fluorophenylboronic acid MIDA ester?
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To request a sample or a quote, please contact our sales department via the website or email, providing your specific requirements and shipping details.
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